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Literature summary extracted from

  • Brown, K.A.; Boerboom, D.; Bouchard, N.; Dore, M.; Lussier, J.G.; Sirois, J.
    Human chorionic gonadotropin-dependent induction of an equine aldo-keto reductase (AKR1C23) with 20alpha-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo (2006), J. Mol. Endocrinol., 36, 449-461.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.149 additional information human chorionic gonadotropin induces expression of AKR1C23 Equus caballus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.149 DNA and amino acid sequence determination and analysis, expression analysis of AKR1C23 in preovulatory follicles, overexpression in HEK-293 cells Equus caballus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.149 0.003 0.012 17alpha-hydroxyprogesterone
-
 Equus caballus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H Equus caballus the aldo-keto reductase, AKR1C23, also shows 20alpha-hydroxysteroid dehydrogenase activity in vivo, enzyme regulation in preovulatory follicles and corpora lutea, overview 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.149 Equus caballus Q1XAA8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.149 adrenal gland very low expression rate of AKR1C23 Equus caballus
-
1.1.1.149 brain low expression rate of AKR1C23 Equus caballus
-
1.1.1.149 granulosa cell
-
 Equus caballus
-
1.1.1.149 heart moderate expression rate of AKR1C23 Equus caballus
-
1.1.1.149 kidney moderate expression rate of AKR1C23 Equus caballus
-
1.1.1.149 liver moderate expression rate of AKR1C23 Equus caballus
-
1.1.1.149 lung moderate expression rate of AKR1C23 Equus caballus
-
1.1.1.149 ovarian follicle preovulatory, very high expression rate, expression analysis of AKR1C23, activity during follicular luteinization, overview Equus caballus
-
1.1.1.149 skeletal muscle moderate expression rate of AKR1C23 Equus caballus
-
1.1.1.149 skin very low expression rate of AKR1C23 Equus caballus
-
1.1.1.149 spleen very low expression rate of AKR1C23 Equus caballus
-
1.1.1.149 stomach low expression rate of AKR1C23 Equus caballus
-
1.1.1.149 testis very high expression rate of AKR1C23 Equus caballus
-
1.1.1.149 thymus very low expression rate of AKR1C23 Equus caballus
-
1.1.1.149 uterus low expression rate of AKR1C23 Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H
-
 Equus caballus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H the aldo-keto reductase, AKR1C23, also shows 20alpha-hydroxysteroid dehydrogenase activity in vivo, enzyme regulation in preovulatory follicles and corpora lutea, overview Equus caballus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.149 AKR1C23
-
 Equus caballus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.149 NAD(P)+
-
 Equus caballus
1.1.1.149 NAD(P)H
-
 Equus caballus