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Literature summary extracted from

  • Dong, J.; Liu, J.; Lou, B.; Li, Z.; Ye, X.; Wu, M.; Jiang, X.C.
    Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice (2006), J. Lipid Res., 47, 1307-1314.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.8.27 medicine adenovirus-mediated SMS1 overexpression increases lipoprotein atherogenic potential. Such an effect may contribute to the increased plasma sphingomyelin levels observed in animal models of atherosclerosis and in human patients with coronary artery disease Mus musculus
2.7.8.27 medicine adenovirus-mediated SMS2 overexpression increases lipoprotein atherogenic potential. Such an effect may contribute to the increased plasma sphingomyelin levels observed in animal models of atherosclerosis and in human patients with coronary artery disease Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.27 adenovirus approach to overexpress SMS1 in mice to investigate the relationship between sphingomyelin synthase and sphingomyelin metabolism Mus musculus
2.7.8.27 adenovirus approach to overexpress SMS2 in mice to investigate the relationship between sphingomyelin synthase and sphingomyelin metabolism Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Mus musculus Q8VCQ6
-
-
2.7.8.27 Mus musculus Q9D4B1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine + phosphatidylcholine
-
 Mus musculus N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS1
-
 Mus musculus
2.7.8.27 SMS2
-
 Mus musculus
2.7.8.27 sphingomyelin synthases 1
-
 Mus musculus
2.7.8.27 sphingomyelin synthases 2
-
 Mus musculus