EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.11 | additional information | MsrA is upregulated by UVA radiation in keratinocytes | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | Homo sapiens | the enzyme protects the epidermis cells against irradiation and oxidative damages, overview | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.4.11 | Homo sapiens | - |
female caucasian individuals | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.4.11 | epidermis | - |
Homo sapiens | - |
1.8.4.11 | HaCaT cell | primary keratinocytes, expression level at normal light and UV-light conditions | Homo sapiens | - |
1.8.4.11 | skin | accumulation in the upper dermis | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.11 | His6-Ala-Ala-Gln-MetO-Ile + DTT | - |
Homo sapiens | His6-Ala-Ala-Gln-Met-Ile + DTT disulfide + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine-(S)-S-oxide + thioredoxin | the enzyme protects the epidermis cells against irradiation and oxidative damages, overview | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.4.11 | MsrA | - |
Homo sapiens |
1.8.4.11 | peptide methionine S-sulfoxide reductase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.8.4.11 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.8.4.11 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.11 | dithiothreitol | - |
Homo sapiens | |
1.8.4.11 | thioredoxin | - |
Homo sapiens |