BRENDA - Enzyme Database

Human cytomegalovirus requires cellular deoxycytidylate deaminase for replication in quiescent cells

Gribaudo, G.; Riera, L.; Caposio, P.; Maley, F.; Landolfo, S.; J. Gen. Virol. 84, 1437-1441 (2003)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
additional information
infection with the human cytomegalovirus upregulates the enzyme involved in thymidylate synthesis especially the dCMP deaminase, but not the dUTPase, overview
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Homo sapiens
the enzyme plays a key role in the thymidylate synthase, pathway overview
dUMP + NH3
-
-
?
3.5.4.12
additional information
Homo sapiens
the human cytomegalovirus requires the cellular host dCMP deaminase for replication in quiescent cells, overview
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.4.12
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.12
HELF cell
quiescent cells infected with human cytomegalovirus, HCMV
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
dCMP + H2O
-
669680
Homo sapiens
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
the enzyme plays a key role in the thymidylate synthase, pathway overview
669680
Homo sapiens
dUMP + NH3
-
-
-
?
3.5.4.12
additional information
the human cytomegalovirus requires the cellular host dCMP deaminase for replication in quiescent cells, overview
669680
Homo sapiens
?
-
-
-
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
additional information
infection with the human cytomegalovirus upregulates the enzyme involved in thymidylate synthesis especially the dCMP deaminase, but not the dUTPase, overview
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Homo sapiens
the enzyme plays a key role in the thymidylate synthase, pathway overview
dUMP + NH3
-
-
?
3.5.4.12
additional information
Homo sapiens
the human cytomegalovirus requires the cellular host dCMP deaminase for replication in quiescent cells, overview
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.12
HELF cell
quiescent cells infected with human cytomegalovirus, HCMV
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
dCMP + H2O
-
669680
Homo sapiens
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
the enzyme plays a key role in the thymidylate synthase, pathway overview
669680
Homo sapiens
dUMP + NH3
-
-
-
?
3.5.4.12
additional information
the human cytomegalovirus requires the cellular host dCMP deaminase for replication in quiescent cells, overview
669680
Homo sapiens
?
-
-
-
-