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Literature summary extracted from

  • Lee, N.P.; Mruk, D.D.; Xia, W.; Cheng, C.Y.
    Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes (2007), J. Endocrinol., 192, 17-32.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.27 additional information induction of SMS2 during Adjudin-induced AJ restructuring and disruption Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.27 gene SMS2 from testis, DNA and amino acid sequence determination and analysis, sequence comparison, tissue expression analysis, overview Rattus norvegicus
2.7.8.27 SMS2 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.27 acrosome SMS2 associates with the developing acrosome beginning in late round spermatids through elongating spermatids. SMS2 may play a crucial role in the arosome formation Rattus norvegicus
-
-
2.7.8.27 cell membrane
-
 Rattus norvegicus
-
-
2.7.8.27 membrane
-
 Rattus norvegicus 16020
-
2.7.8.27 additional information SMS2 topology with intracellular, membrane, and extracellular protein parts, detailed overview, SMS2 tissue expression analysis by immunohistochemistry, immunofluorescence microscopy, and immunogold electron microscopy, overview Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 additional information Rattus norvegicus SMS2 may play a crucial role in the lipid metabolism in arosome formation and the plasma membrane restructuring from late round spermatids to early elongating spermatids ?
-
 ?
2.7.8.27 phosphatidylcholine + ceramide Rattus norvegicus SMS2 is crucial to cellular lipid metabolism sphingomyelin + diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Rattus norvegicus
-
-
-
2.7.8.27 Rattus norvegicus Q4JM44 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 germ cell primary culture Rattus norvegicus
-
2.7.8.27 additional information no activity in Sertoli cells Rattus norvegicus
-
2.7.8.27 seminiferous epithelium
-
 Rattus norvegicus
-
2.7.8.27 seminiferous tubule
-
 Rattus norvegicus
-
2.7.8.27 Sertoli cell primary culture Rattus norvegicus
-
2.7.8.27 spermatid expression of SMS2 is limited to late round spermatids and elongating spermatids, not detected in late elongate spermatids. SMS2 associates with the developing acrosome beginning in late round spermatids through elongating spermatids and in the cell membrane. SMS2 may play a crucial role in the plasma membrane restructuring from late round spermatids to early elongating spermatids Rattus norvegicus
-
2.7.8.27 testis
-
 Rattus norvegicus
-
2.7.8.27 testis seminiferous epithelium of adult rat Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 additional information SMS2 may play a crucial role in the lipid metabolism in arosome formation and the plasma membrane restructuring from late round spermatids to early elongating spermatids Rattus norvegicus ?
-
 ?
2.7.8.27 phosphatidylcholine + ceramide
-
 Rattus norvegicus sphingomyelin + diacylglycerol
-
 ?
2.7.8.27 phosphatidylcholine + ceramide SMS2 is crucial to cellular lipid metabolism Rattus norvegicus sphingomyelin + diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SM synthase
-
 Rattus norvegicus
2.7.8.27 SMS2
-
 Rattus norvegicus
2.7.8.27 sphingomyelin synthase 2
-
 Rattus norvegicus