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Literature summary extracted from

  • Hayakawa, K.; Guo, L.; Terentyeva, E.A.; Li, X.K.; Kimura, H.; Hirano, M.; Yoshikawa, K.; Nagamine, T.; Katsumata, N.; Ogata, T.; Tanaka, T.
    Determination of specific activities and kinetic constants of biotinidase and lipoamidase in LEW rat and Lactobacillus casei (Shirota) (2006), J. Chromatogr. B, 844, 240-250.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.12 biotin competitive Rattus norvegicus
3.5.1.12 lipoic acid competitive Lacticaseibacillus casei
3.5.1.12 PCMB noncompetitive Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.12 0.00383
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from supernatant fraction Lacticaseibacillus casei
3.5.1.12 0.00556
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from membrane fraction Lacticaseibacillus casei
3.5.1.12 0.0167
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from membrane and supernatant fraction Mus musculus
3.5.1.12 0.75
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from upper labial skin, male rat Rattus norvegicus
3.5.1.12 1.18
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from upper labial skin, female rat Rattus norvegicus
3.5.1.12 1.71
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from bone marrow, male rat Rattus norvegicus
3.5.1.12 1.82
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from lower labial skin, female rat Rattus norvegicus
3.5.1.12 1.87
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from diaphragm, female rat Rattus norvegicus
3.5.1.12 1.87
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from diaphragm, male rat Rattus norvegicus
3.5.1.12 2.43
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from cerebrum, male rat Rattus norvegicus
3.5.1.12 2.67
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from small intestine, female rat Rattus norvegicus
3.5.1.12 2.97
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from cerebrum, female rat Rattus norvegicus
3.5.1.12 3.36
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from stomach, male rat Rattus norvegicus
3.5.1.12 3.69
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from lung, female rat Rattus norvegicus
3.5.1.12 3.7 5 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from large intestine, female rat Rattus norvegicus
3.5.1.12 3.87
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from pancreatic head, female rat Rattus norvegicus
3.5.1.12 3.88
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from stomach (corpus), male rat Rattus norvegicus
3.5.1.12 3.9
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from uterus, female rat Rattus norvegicus
3.5.1.12 4.15
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from bone marrow, female rat Rattus norvegicus
3.5.1.12 4.17
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from cerebellum, female rat Rattus norvegicus
3.5.1.12 4.17
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from cerebellum, male rat Rattus norvegicus
3.5.1.12 4.27
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from large intestine, male rat Rattus norvegicus
3.5.1.12 4.39
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from cerebrum, male rat Rattus norvegicus
3.5.1.12 4.39
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from pancreatic tail, female rat Rattus norvegicus
3.5.1.12 4.63
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from cerebrum, female rat Rattus norvegicus
3.5.1.12 4.77
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from lower labial skin, male rat Rattus norvegicus
3.5.1.12 4.77
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from tigh muscle, male rat Rattus norvegicus
3.5.1.12 5.41
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from spleen, female rat Rattus norvegicus
3.5.1.12 5.45
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from ovary, female rat Rattus norvegicus
3.5.1.12 5.49
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from heart, male rat Rattus norvegicus
3.5.1.12 5.81
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from small intestine (jejunum), male rat Rattus norvegicus
3.5.1.12 6.17
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from testis, male rat Rattus norvegicus
3.5.1.12 6.25
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from tigh muscle, female rat Rattus norvegicus
3.5.1.12 6.76
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from liver, female rat Rattus norvegicus
3.5.1.12 7.75
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from small intestine (duodenum), male rat Rattus norvegicus
3.5.1.12 7.91
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from lung, male rat Rattus norvegicus
3.5.1.12 7.97
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from kidney, female rat Rattus norvegicus
3.5.1.12 8.23
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from liver, male rat Rattus norvegicus
3.5.1.12 8.58
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from spleen, male rat Rattus norvegicus
3.5.1.12 10.1
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from esophagus, female rat Rattus norvegicus
3.5.1.12 10.1
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from esophagus, male rat Rattus norvegicus
3.5.1.12 11
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from abdominal skin, female rat Rattus norvegicus
3.5.1.12 11.6
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from stomach (pylori), female rat Rattus norvegicus
3.5.1.12 11.6
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from stomach, male rat Rattus norvegicus
3.5.1.12 11.9
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from abdominal skin, male rat Rattus norvegicus
3.5.1.12 11.9
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from kidney, male rat Rattus norvegicus
3.5.1.12 12.1
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from small intestine (ileum), male rat Rattus norvegicus
3.5.1.12 19.2
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from pancreatic head, male rat Rattus norvegicus
3.5.1.12 21.7
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from pancreatic tail, male rat Rattus norvegicus
3.5.1.12 24.1
-
 Biotinyl-6-aminoquinoline pH 7.0, 37°C, enzyme from heart, female rat Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.12 membrane
-
 Lacticaseibacillus casei 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.12 Lacticaseibacillus casei
-
 Shirota strain
-
3.5.1.12 Lacticaseibacillus casei Shirota
-
 Shirota strain
-
3.5.1.12 Mus musculus
-
-
-
3.5.1.12 Rattus norvegicus
-
 LES rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.12 bone marrow
-
 Rattus norvegicus
-
3.5.1.12 cerebellum
-
 Rattus norvegicus
-
3.5.1.12 cerebrum
-
 Rattus norvegicus
-
3.5.1.12 diaphragm
-
 Rattus norvegicus
-
3.5.1.12 esophagus
-
 Rattus norvegicus
-
3.5.1.12 heart
-
 Rattus norvegicus
-
3.5.1.12 kidney
-
 Mus musculus
-
3.5.1.12 kidney
-
 Rattus norvegicus
-
3.5.1.12 large intestine
-
 Rattus norvegicus
-
3.5.1.12 liver
-
 Rattus norvegicus
-
3.5.1.12 lung
-
 Rattus norvegicus
-
3.5.1.12 muscle
-
 Rattus norvegicus
-
3.5.1.12 ovary
-
 Rattus norvegicus
-
3.5.1.12 pancreas
-
 Rattus norvegicus
-
3.5.1.12 skin
-
 Rattus norvegicus
-
3.5.1.12 skin abdominal Rattus norvegicus
-
3.5.1.12 small intestine
-
 Rattus norvegicus
-
3.5.1.12 spleen
-
 Rattus norvegicus
-
3.5.1.12 stomach
-
 Rattus norvegicus
-
3.5.1.12 testis
-
 Rattus norvegicus
-
3.5.1.12 uterus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.12 biotinyl-6-aminoquinoline + H2O
-
 Mus musculus biotin + 6-aminoquinoline
-
 ?
3.5.1.12 biotinyl-6-aminoquinoline + H2O
-
 Rattus norvegicus biotin + 6-aminoquinoline
-
 ?
3.5.1.12 biotinyl-6-aminoquinoline + H2O
-
 Lacticaseibacillus casei biotin + 6-aminoquinoline
-
 ?
3.5.1.12 biotinyl-6-aminoquinoline + H2O
-
 Lacticaseibacillus casei Shirota biotin + 6-aminoquinoline
-
 ?