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Literature summary extracted from

  • McCormick, K.L.; Wang, X.; Mick, G.J.
    Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes (2006), J. Biol. Chem., 281, 341-347.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.146 dehydroandrostenedione activates isozyme 11beta-HSD1 3fold Rattus norvegicus
1.1.1.146 norepinephrine activates isozyme 11beta-HSD1 2.5fold Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 endoplasmic reticulum intraluminal compartment Rattus norvegicus 5783
-
1.1.1.146 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 11-dehydrocorticosterone + NADPH Rattus norvegicus isozyme 11beta-HSD1, biological activation of the glucocorticoid corticosterone + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+ Rattus norvegicus isozyme 11beta-HSD1, biological activation of the glucocorticoid cortisol + NADP+
-
 ?
1.1.1.146 additional information Rattus norvegicus isozyme 11beta-HSD1 is regulated by the pentose phosphate pathway flux, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Rattus norvegicus
-
 isozyme 11beta-HSD1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 adipocyte
-
 Rattus norvegicus
-
1.1.1.146 adipose tissue
-
 Rattus norvegicus
-
1.1.1.146 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Rattus norvegicus corticosterone + NADP+
-
 ?
1.1.1.146 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1, biological activation of the glucocorticoid Rattus norvegicus corticosterone + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+ isozyme 11beta-HSD1 Rattus norvegicus cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+ isozyme 11beta-HSD1, biological activation of the glucocorticoid Rattus norvegicus cortisol + NADP+
-
 ?
1.1.1.146 additional information isozyme 11beta-HSD1 is regulated by the pentose phosphate pathway flux, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Rattus norvegicus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.146 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.146 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADPH
-
 Rattus norvegicus