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Literature summary extracted from

  • Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
    Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor (2006), J. Biol. Chem., 281, 11050-11057.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.61 degradation PC1/3 is essential and sufficient for the production of the intestinal incretin hormone GIP Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.61 adenovirus construct expressing PC1/3 Mus musculus
3.4.21.61 GH4 cells co-transfected with preproGIP and PC1/3 Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.61 additional information PC1/3-deficient mice show severely impaired processing to GIP Mus musculus
3.4.21.93 additional information PC1/3-deficient cells do not show preproGIP processing Mus musculus
3.4.21.94 additional information PC2-deficient cells do not show alterations in glucose-dependent insulinotropic polypeptide precursor processing activity Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.93 glucose-dependent insulinotropic polypeptide precursor + H2O Mus musculus PC1/3 is essential for pro-GIP processing glucose-dependent insulinotropic polypeptide + propeptide of glucose-dependent insulinotropic polypeptide GIP ?
3.4.21.94 additional information Mus musculus glucose-dependent insulinotropic polypeptide precursor is no substrate of PC2 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.61 Mus musculus
-
-
-
3.4.21.61 Rattus norvegicus
-
-
-
3.4.21.93 Mus musculus
-
-
-
3.4.21.94 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.61 AtT-20 cell expresses high levels of endogenous PC1/3 Mus musculus
-
3.4.21.61 intestine co-localization of GIP and PC1/3 Mus musculus
-
3.4.21.61 additional information alpha-TC1.9 cells do not express PC1/3 Mus musculus
-
3.4.21.61 additional information GH4 cell expresses low levels of PC1/3 Rattus norvegicus
-
3.4.21.61 pancreatic islet
-
 Mus musculus
-
3.4.21.61 pancreatic islet
-
 Rattus norvegicus
-
3.4.21.93 alpha-TC1.9 cell pancreatic alpha-cell line, low expression level Mus musculus
-
3.4.21.93 AtT-20 cell pituitary gland cell line Mus musculus
-
3.4.21.93 intestine
-
 Mus musculus
-
3.4.21.94 alpha-TC1.9 cell pancreatic alpha-cell line Mus musculus
-
3.4.21.94 AtT-20 cell pituitary gland cell line, low expression level Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.61 proGIP + H2O
-
 Mus musculus GIP
-
 ?
3.4.21.61 proGIP + H2O
-
 Rattus norvegicus GIP
-
 ?
3.4.21.93 glucose-dependent insulinotropic polypeptide precursor + H2O PC1/3 is essential for pro-GIP processing Mus musculus glucose-dependent insulinotropic polypeptide + propeptide of glucose-dependent insulinotropic polypeptide GIP ?
3.4.21.93 glucose-dependent insulinotropic polypeptide precursor + H2O i.e. pro-GIP, incretin hormone Mus musculus glucose-dependent insulinotropic polypeptide + propeptide of glucose-dependent insulinotropic polypeptide GIP ?
3.4.21.94 additional information glucose-dependent insulinotropic polypeptide precursor is no substrate of PC2 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.61 PC 1/3
-
 Mus musculus
3.4.21.61 PC 1/3
-
 Rattus norvegicus
3.4.21.61 prohormone convertase 1/3
-
 Mus musculus
3.4.21.61 prohormone convertase 1/3
-
 Rattus norvegicus
3.4.21.93 PC1/3
-
 Mus musculus
3.4.21.93 prohormone convertase 1/3
-
 Mus musculus
3.4.21.94 PC2
-
 Mus musculus
3.4.21.94 prohormone convertase 2
-
 Mus musculus