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Literature summary extracted from

  • Kil, I.S.; Park, J.W.
    Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation (2005), J. Biol. Chem., 280, 10846-10854.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 glutathione oxidized glutathione leads to enzyme inactivation with simultaneous formation of a mixed disulfide between glutathione and the cysteine residues of enzyme. Enzymical reactivation by glutaredoxin2 in presence of reduced glutathione Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.42 mitochondrion
-
 Sus scrofa 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 additional information Sus scrofa during oxidative stress, enzyme activity appears to be modulated through enzymatic glutathionylation and deglutathionylation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Sus scrofa
-
-
-

Renatured (Commentary)

EC Number Renatured (Comment) Organism
1.1.1.42 oxidized glutathione leads to enzyme inactivation with simultaneous formation of a mixed disulfide between glutathione and the cysteine residues of enzyme. Enzymical reactivation by glutaredoxin2 in presence of reduced glutathione Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 additional information during oxidative stress, enzyme activity appears to be modulated through enzymatic glutathionylation and deglutathionylation Sus scrofa ?
-
 ?