Literature summary extracted from

Nowak, N.; Lotter, H.; Tannich, E.; Bruchhaus, I.
Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity (2004), J. Biol. Chem., 279, 38260-38266.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.22.35	additional information	expression of ehpc1 and ehpc2 is increased in presence of E64 in E64-sensitive and E64-resistant amoebae, overview	Entamoeba histolytica

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.22.35	4-hydroxymercuribenzoate	E64 inhibits cell growth and is cytopathic/lethal for E64-sensitive and E64-resistant amoebae	Entamoeba histolytica
3.4.22.35	L-trans-epoxysuccinyl-(ethoxy)-Leu-3-methylbutylamide ethyl ester	i.e. E64d, inhibits cell growth and is cytopathic/lethal for E64-sensitive and E64-resistant amoebae	Entamoeba histolytica
3.4.22.35	L-trans-epoxysuccinyl-Leu-4-guanidinobutylamide	i.e. E64, inhibits cell growth in E64-resistant by about 80% and is cytopathic/lethal for E64-sensitive amoebae	Entamoeba histolytica
3.4.22.35	Z-Phe-Ala-diazomethylketone	E64 inhibits cell growth and is cytopathic/lethal for E64-sensitive and E64-resistant amoebae	Entamoeba histolytica
3.4.22.35	Z-Phe-Phe-diazomethylketone	25% inhibition of E64-sensitive and E64-resistant amoba growth	Entamoeba histolytica

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.35	Entamoeba histolytica	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.35	trophozoite	-	Entamoeba histolytica	-

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Release 2023.1 (January 2023)