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Literature summary extracted from

  • Crick, D.C.; Schulbach, M.C.; Zink, E.E.; Macchia, M.; Barontini, S.; Besra, G.S.; Brennan, P.J.
    Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis (2000), J. Bacteriol., 182, 5771-5778.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.86
-
 Mycolicibacterium smegmatis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.68 cytosol major activity Mycolicibacterium smegmatis 5829
-
2.5.1.68 cytosol major activity Mycobacterium tuberculosis 5829
-
2.5.1.68 membrane minor activity Mycolicibacterium smegmatis 16020
-
2.5.1.68 membrane minor activity Mycobacterium tuberculosis 16020
-
2.5.1.86 membrane associated Mycolicibacterium smegmatis 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.68 Mg2+ activates Mycolicibacterium smegmatis
2.5.1.68 Mg2+ activates Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate Mycolicibacterium smegmatis step in polyprenylphosphate biosynthesis, overview (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate Mycobacterium tuberculosis step in polyprenylphosphate biosynthesis, overview (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate Mycobacterium tuberculosis H37Rv step in polyprenylphosphate biosynthesis, overview (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
2.5.1.86 (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate Mycolicibacterium smegmatis the enzyme is involved in decaprenyl phosphate synthesis, that is important in the rate of bacterial growth and the synthesis of cell wall components 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.68 Mycobacterium tuberculosis
-
-
-
2.5.1.68 Mycobacterium tuberculosis H37Rv
-
-
-
2.5.1.68 Mycolicibacterium smegmatis
-
-
-
2.5.1.86 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate stereospecific reaction Mycolicibacterium smegmatis (2Z,6E)-farnesyl diphosphate + diphosphate i.e. omega,E,Z-farnesyl diphosphate ?
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate stereospecific reaction Mycobacterium tuberculosis (2Z,6E)-farnesyl diphosphate + diphosphate i.e. omega,E,Z-farnesyl diphosphate ?
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate step in polyprenylphosphate biosynthesis, overview Mycolicibacterium smegmatis (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate step in polyprenylphosphate biosynthesis, overview Mycobacterium tuberculosis (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate stereospecific reaction Mycobacterium tuberculosis H37Rv (2Z,6E)-farnesyl diphosphate + diphosphate i.e. omega,E,Z-farnesyl diphosphate ?
2.5.1.68 geranyl diphosphate + isopentenyl diphosphate step in polyprenylphosphate biosynthesis, overview Mycobacterium tuberculosis H37Rv (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
2.5.1.86 (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
-
 Mycolicibacterium smegmatis 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
 ?
2.5.1.86 (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate the enzyme is involved in decaprenyl phosphate synthesis, that is important in the rate of bacterial growth and the synthesis of cell wall components Mycolicibacterium smegmatis 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.68 37
-
 assay at Mycolicibacterium smegmatis
2.5.1.68 37
-
 assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.68 7.9
-
 assay at Mycolicibacterium smegmatis
2.5.1.68 7.9
-
 assay at Mycobacterium tuberculosis