BRENDA - Enzyme Database

Inhibition of angiotensin converting enzyme activity by flavanol-rich foods

Actis-Goretta, L.; Ottaviani, J.I.; Fraga, C.G.; J. Agric. Food Chem. 54, 229-234 (2006)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.15.1
(+)-catechin
IC50: about 1.6 mM
Oryctolagus cuniculus
3.4.15.1
(-)-epicatechin
IC50: about 1.7 mM
Oryctolagus cuniculus
3.4.15.1
caffeic acid
IC50: about 1.7 mM
Oryctolagus cuniculus
3.4.15.1
chlorogenic acid
IC50: about 1.8 mM
Oryctolagus cuniculus
3.4.15.1
epigallocatechin
IC50: about 0.3 mM
Oryctolagus cuniculus
3.4.15.1
flavanol
flavanols either isolated or present in foods can inhibit enzyme activity
Oryctolagus cuniculus
3.4.15.1
gallic acid
IC50 : about 1.7 mM
Oryctolagus cuniculus
3.4.15.1
kaempferol
IC50: about 1.2 mM
Oryctolagus cuniculus
3.4.15.1
quercetin
IC50: about 2.0 mM
Oryctolagus cuniculus
3.4.15.1
resveratrol
IC50: about 1.6 mM
Oryctolagus cuniculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.4.15.1
Oryctolagus cuniculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.15.1
lung
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.4.15.1
hippuryl-His-Leu + H2O
-
669026
Oryctolagus cuniculus
hippuric acid + His-Leu
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.4.15.1
0.3
-
IC50: about 0.3 mM
Oryctolagus cuniculus
epigallocatechin
3.4.15.1
1.2
-
IC50: about 1.2 mM
Oryctolagus cuniculus
kaempferol
3.4.15.1
1.6
-
IC50: about 1.6 mM
Oryctolagus cuniculus
(+)-catechin
3.4.15.1
1.6
-
IC50: about 1.6 mM
Oryctolagus cuniculus
resveratrol
3.4.15.1
1.7
-
IC50: about 1.7 mM
Oryctolagus cuniculus
caffeic acid
3.4.15.1
1.7
-
IC50: about 1.7 mM
Oryctolagus cuniculus
(-)-epicatechin
3.4.15.1
1.7
-
IC50 : about 1.7 mM
Oryctolagus cuniculus
gallic acid
3.4.15.1
1.8
-
IC50: about 1.8 mM
Oryctolagus cuniculus
chlorogenic acid
3.4.15.1
2
-
IC50: about 2.0 mM
Oryctolagus cuniculus
quercetin
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.4.15.1
0.3
-
IC50: about 0.3 mM
Oryctolagus cuniculus
epigallocatechin
3.4.15.1
1.2
-
IC50: about 1.2 mM
Oryctolagus cuniculus
kaempferol
3.4.15.1
1.6
-
IC50: about 1.6 mM
Oryctolagus cuniculus
(+)-catechin
3.4.15.1
1.6
-
IC50: about 1.6 mM
Oryctolagus cuniculus
resveratrol
3.4.15.1
1.7
-
IC50: about 1.7 mM
Oryctolagus cuniculus
caffeic acid
3.4.15.1
1.7
-
IC50: about 1.7 mM
Oryctolagus cuniculus
(-)-epicatechin
3.4.15.1
1.7
-
IC50 : about 1.7 mM
Oryctolagus cuniculus
gallic acid
3.4.15.1
1.8
-
IC50: about 1.8 mM
Oryctolagus cuniculus
chlorogenic acid
3.4.15.1
2
-
IC50: about 2.0 mM
Oryctolagus cuniculus
quercetin
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.15.1
(+)-catechin
IC50: about 1.6 mM
Oryctolagus cuniculus
3.4.15.1
(-)-epicatechin
IC50: about 1.7 mM
Oryctolagus cuniculus
3.4.15.1
caffeic acid
IC50: about 1.7 mM
Oryctolagus cuniculus
3.4.15.1
chlorogenic acid
IC50: about 1.8 mM
Oryctolagus cuniculus
3.4.15.1
epigallocatechin
IC50: about 0.3 mM
Oryctolagus cuniculus
3.4.15.1
flavanol
flavanols either isolated or present in foods can inhibit enzyme activity
Oryctolagus cuniculus
3.4.15.1
gallic acid
IC50 : about 1.7 mM
Oryctolagus cuniculus
3.4.15.1
kaempferol
IC50: about 1.2 mM
Oryctolagus cuniculus
3.4.15.1
quercetin
IC50: about 2.0 mM
Oryctolagus cuniculus
3.4.15.1
resveratrol
IC50: about 1.6 mM
Oryctolagus cuniculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.15.1
lung
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.4.15.1
hippuryl-His-Leu + H2O
-
669026
Oryctolagus cuniculus
hippuric acid + His-Leu
-
-
-
?