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Literature summary extracted from

  • Park, Y.S.; Jang, H.J.; Lee, K.H.; Hahn, T.R.; Paik, Y.S.
    Prolyl endopeptidase inhibitory activity of unsaturated fatty acids (2006), J. Agric. Food Chem., 54, 1238-1242.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.26 medicine enzyme levels in postmortem brains of Alzheimer’s disease patients reveal significant increases in enzyme activity. Use of unsaturated fatty acids in preventing memory loss Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 arachidonic acid 50% inhibition at 0.0534 mM Homo sapiens
3.4.21.26 docosahexaenoic acid 50% inhibition at 0.0462 mM Homo sapiens
3.4.21.26 eicosapentaenoic acid 50% inhibition at 0.0994 mM Homo sapiens
3.4.21.26 linoleic acid 50% inhibition at 0.0438 mM Homo sapiens
3.4.21.26 oleic acid 50% inhibition at 0.0236 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Homo sapiens
-
 patients with Alzheimer’s disease
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.26 0.0267
-
 oleic acid 37°C, pH 7.0 Homo sapiens
3.4.21.26 0.051
-
 linoleic acid 37°C, pH 7.0 Homo sapiens
3.4.21.26 0.089
-
 docosahexaenoic acid 37°C, pH 7.0 Homo sapiens
3.4.21.26 0.0913
-
 arachidonic acid 37°C, pH 7.0 Homo sapiens
3.4.21.26 0.2475
-
 eicosapentaenoic acid 37°C, pH 7.0 Homo sapiens