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Literature summary extracted from

  • Mezyk-Kopec, R.; Bzowska, M.; Potempa, J.; Bzowska, M.; Jura, N.; Sroka, A.; Black, R.A.; Bereta, J.
    Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis (2005), Infect. Immun., 73, 1506-1514.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.37 leupeptin
-
Porphyromonas gingivalis
3.4.22.47 Z-Phe-Lys-2,4,6-trimethyl-benzoyloxymethyl-ketone specific inhibition of Kgp Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.37 TNFalpha + H2O Porphyromonas gingivalis inactivation by degradation of human TNFalpha on host cell surface and recombinant fibroblast cell surface, leading to inhibition of biological functions of TNFalpha, overview ?
-
?
3.4.22.47 TNFalpha + H2O Porphyromonas gingivalis degradation, leading to inhibition of biological functions of TNFalpha, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.37 Porphyromonas gingivalis
-
arginine-specific enzyme forms HRgpA and RgpB
-
3.4.22.47 Porphyromonas gingivalis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.37 native HRgpA and RgpB Porphyromonas gingivalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.37 TNFalpha + H2O inactivation by degradation of human TNFalpha on host cell surface and recombinant fibroblast cell surface, leading to inhibition of biological functions of TNFalpha, overview Porphyromonas gingivalis ?
-
?
3.4.22.37 TNFalpha + H2O degradation, high activity with HRgpA, moderate activity with RgpB Porphyromonas gingivalis ?
-
?
3.4.22.47 TNFalpha + H2O degradation Porphyromonas gingivalis ?
-
?
3.4.22.47 TNFalpha + H2O degradation, leading to inhibition of biological functions of TNFalpha, overview Porphyromonas gingivalis ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.37 HRgpA
-
Porphyromonas gingivalis
3.4.22.37 RgpB
-
Porphyromonas gingivalis
3.4.22.47 KGP
-
Porphyromonas gingivalis
3.4.22.47 lysine-specific proteinase
-
Porphyromonas gingivalis