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Literature summary extracted from

  • Shen, L.; Sigal, L.J.; Boes, M.; Rock, K.L.
    Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo (2004), Immunity, 21, 155-165.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.27 additional information cathepsin S-deficient mutant mice lack the TAP-independent vacuolar pathway of MHC class I crosspresentation, and have reduced crosspriming to particulate and cell-associated antigens as well as to influenza virus, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.27 leupeptin
-
 Mus musculus
3.4.22.27 additional information no inhibition by proteasome inhibitors Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.27 endosome
-
 Mus musculus 5768
-
3.4.22.27 phagosome
-
 Mus musculus
-
-
3.4.22.27 vacuole
-
 Mus musculus 5773
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.27 additional information Mus musculus cathepsin S, a cysteine protease, plays an important role in generating peptides for the vacuolar, TAP-independent MHC class I cross-presentation in vivo ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.27 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.27 B-cell
-
 Mus musculus
-
3.4.22.27 dendritic cell
-
 Mus musculus
-
3.4.22.27 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.27 additional information cathepsin S, a cysteine protease, plays an important role in generating peptides for the vacuolar, TAP-independent MHC class I cross-presentation in vivo Mus musculus ?
-
 ?