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Literature summary extracted from
- Procollagen C-endopeptidase (2004), Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 609-617.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.19 | Enhancer glycoprotein | stimulates activity | Homo sapiens | |
| 3.4.24.19 | TGFbeta | increases the expression of BMP-1 and Tld in human dermal fibroblasts | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.19 | additional information | involved in deposition of collagen fibrils in the extracellular matrix following processing of procollagen propeptides, dorsoventral patterning through cleavage of chordin, collagen and elastin cross-linking by processing of inactive precursors of lysyl oxidases, proteoglycan maturation and assembly of the dermal-epidermal junction by processing of laminin 5 chains and cleaving the C-propeptide of type VII procollagen | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.19 | expressed in baculovirus-infected Sf21 insect cells, HT-180 cells, 293-EBNA cells or COS-7 cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.24.19 | additional information | homozygous null mice lacking PCBs encoded by BMP-1 are perinatally lethal and have reduced ossification of skull bones and defects in formation of the ventral body wall, procollagen processing and collagen fibrillogenesis | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.19 | 1,10-phenanthroline | - |
Homo sapiens |  |
| 3.4.24.19 | Ac-Met-Val-Gly-Asp-Asp-Pro-Tyr-Asn-NH2 | weak inhibitor | Homo sapiens | |
| 3.4.24.19 | acidic dipeptide hydroxamate derivates | mimic the location of aspartic acid residues in the P1' and P2' positions of the PCP cleavage site in procollagen | Homo sapiens | |
| 3.4.24.19 | alpha2-Macroglobulin | - |
Homo sapiens | |
| 3.4.24.19 | Arg | inhibits at 5-10 mM | Homo sapiens | |
| 3.4.24.19 | CdCl2 | - |
Homo sapiens | |
| 3.4.24.19 | concanavalin A | - |
Homo sapiens | |
| 3.4.24.19 | CuCl2 | inhibits at 0.01-0.1 mM | Homo sapiens | |
| 3.4.24.19 | di-/tripeptidic hydroxamic acid derivates | - |
Homo sapiens | |
| 3.4.24.19 | DTT | - |
Homo sapiens | |
| 3.4.24.19 | EDTA | - |
Homo sapiens | |
| 3.4.24.19 | EGTA | - |
Homo sapiens | |
| 3.4.24.19 | Lys | inhibits at 5-10 mM | Homo sapiens | |
| 3.4.24.19 | N-ethylmaleimide | inhibits at 20 mM | Homo sapiens | |
| 3.4.24.19 | NaCl | inhibits at 200-500 mM | Homo sapiens | |
| 3.4.24.19 | small molecule ox(adi)azolyl-hydroxamic acid derivates | - |
Homo sapiens | |
| 3.4.24.19 | sulfonamide hydrxamate derivates of ornithine analogs | - |
Homo sapiens | |
| 3.4.24.19 | Tris-HCl buffer | inhibits at 200-500 mM | Homo sapiens | |
| 3.4.24.19 | Tyr-Tyr-Arg-Ala-Asp-Asp-Ala | weak inhibitor | Homo sapiens | |
| 3.4.24.19 | ZnCl2 | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.19 | cytoplasm | - |
Strongylocentrotus purpuratus | 5737 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.19 | Ca2+ | required for activity | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.19 | 10700 | - |
immunoblotting, XBMP1-B in adults | Xenopus laevis |
| 3.4.24.19 | 63000 | - |
XBMP1-A in unfertilized eggs | Xenopus laevis |
| 3.4.24.19 | 71890 | - |
calculated | Strongylocentrotus purpuratus |
| 3.4.24.19 | 80000 | - |
SDS-PAGE, mature N-gycosylated enzyme | Mus musculus |
| 3.4.24.19 | 80670 | - |
XBMP1-B | Xenopus laevis |
| 3.4.24.19 | 82900 | - |
prepro-BMP1 | Homo sapiens |
| 3.4.24.19 | 100000 | - |
SDS-PAGE, mature N-gycosylated enzyme | Gallus gallus |
| 3.4.24.19 | 110200 | - |
XBMP1-A | Xenopus laevis |
| 3.4.24.19 | 111600 | - |
mTld | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.19 | Gallus gallus | - |
- |
- |
| 3.4.24.19 | Homo sapiens | - |
- |
- |
| 3.4.24.19 | Mus musculus | - |
- |
- |
| 3.4.24.19 | Rattus norvegicus | - |
- |
- |
| 3.4.24.19 | Strongylocentrotus purpuratus | - |
- |
- |
| 3.4.24.19 | Xenopus laevis | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.19 | - |
Gallus gallus |
| 3.4.24.19 | - |
Mus musculus |
| 3.4.24.19 | by anti-Flag affinity column | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.19 | adenocarcinoma cell | gastric epithelial adenocarcinoma stimulated with Helicobacter pylori | Homo sapiens | - |
| 3.4.24.19 | articular cartilage | - |
Homo sapiens | - |
| 3.4.24.19 | articular cartilage | - |
Rattus norvegicus | - |
| 3.4.24.19 | blastula | - |
Xenopus laevis | - |
| 3.4.24.19 | blood | tumor endothelial cells of malignant colorectal tissues | Homo sapiens | - |
| 3.4.24.19 | brain | mTld | Homo sapiens | - |
| 3.4.24.19 | chondrocyte | - |
Homo sapiens | - |
| 3.4.24.19 | chondrocyte | - |
Rattus norvegicus | - |
| 3.4.24.19 | dermis | - |
Homo sapiens | - |
| 3.4.24.19 | egg | - |
Xenopus laevis | - |
| 3.4.24.19 | embryo | - |
Xenopus laevis | - |
| 3.4.24.19 | embryo | in both ectodermal and primary mesenchyme cells in hatched blastula stage | Strongylocentrotus purpuratus | - |
| 3.4.24.19 | embryo | initially expressed at gastrulation stages, later during dorso-ventral patterning of the neural tube in neural crest and ventrally in the caudal notochord and floor plate, and during patterning of the somites | Gallus gallus | - |
| 3.4.24.19 | embryo | throughout the mesenchyme of developing embryonic tissue | Mus musculus | - |
| 3.4.24.19 | epiphysis | - |
Homo sapiens | - |
| 3.4.24.19 | epiphysis | - |
Rattus norvegicus | - |
| 3.4.24.19 | fibroblast | - |
Mus musculus | - |
| 3.4.24.19 | fibroblast | - |
Homo sapiens | - |
| 3.4.24.19 | heart | mTld and BMP-1 | Homo sapiens | - |
| 3.4.24.19 | hindlimb | - |
Xenopus laevis | - |
| 3.4.24.19 | kidney | mTld and BMP-1 | Homo sapiens | - |
| 3.4.24.19 | liver | - |
Mus musculus | - |
| 3.4.24.19 | liver | mTld and BMP-1 | Homo sapiens | - |
| 3.4.24.19 | lung | mTld and BMP-1 | Homo sapiens | - |
| 3.4.24.19 | MG-63 cell | - |
Homo sapiens | - |
| 3.4.24.19 | additional information | in developing membranous and endochondral bones, in sections of murine hind limp and femoral growth plate | Mus musculus | - |
| 3.4.24.19 | additional information | metaphysis | Homo sapiens | - |
| 3.4.24.19 | additional information | metaphysis | Rattus norvegicus | - |
| 3.4.24.19 | osteoblast | - |
Homo sapiens | - |
| 3.4.24.19 | osteoblast | - |
Rattus norvegicus | - |
| 3.4.24.19 | osteoclast | - |
Homo sapiens | - |
| 3.4.24.19 | osteoclast | - |
Rattus norvegicus | - |
| 3.4.24.19 | placenta | - |
Mus musculus | - |
| 3.4.24.19 | placenta | mTld and BMP-1 | Homo sapiens | - |
| 3.4.24.19 | skeletal muscle | mTld and BMP-1 | Homo sapiens | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.4.24.19 | -70°C | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.19 | bovine lysyl oxidase-like precursor protein + H2O | cleaved at a Gly-Asp and Ser-Asp bond | Homo sapiens | ? | - |
? | |
| 3.4.24.19 | chordin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.19 | lamin 5 + H2O | gamma2 chain cleaved at a Gly-Asp bond, also cleavage of alpha3 chain | Homo sapiens | ? | - |
? | |
| 3.4.24.19 | pC-collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.19 | pro-lysyl oxidase + H2O | cleaved at site Met-Val-Gyl-Asp-Asp-Pro | Homo sapiens | ? | - |
? | |
| 3.4.24.19 | probiglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.19 | Procollagen type I + H2O | - |
Homo sapiens | Type I pNcollagen + C-propeptides | - |
? | |
| 3.4.24.19 | procollagen type II + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.19 | procollagen type III + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.19 | procollagen type VII + H2O | cleaved at an Ala-Asp bond | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.19 | BMP-1 | - |
Gallus gallus |
| 3.4.24.19 | BMP-1 | - |
Mus musculus |
| 3.4.24.19 | BMP-1 | - |
Homo sapiens |
| 3.4.24.19 | bone morphogenetic protein 1 | - |
Gallus gallus |
| 3.4.24.19 | bone morphogenetic protein 1 | - |
Mus musculus |
| 3.4.24.19 | bone morphogenetic protein 1 | - |
Homo sapiens |
| 3.4.24.19 | carboxy-terminal procollagen peptidase | - |
Gallus gallus |
| 3.4.24.19 | carboxy-terminal procollagen peptidase | - |
Mus musculus |
| 3.4.24.19 | carboxy-terminal procollagen peptidase | - |
Homo sapiens |
| 3.4.24.19 | carboxy-terminal procollagen peptidase | - |
Xenopus laevis |
| 3.4.24.19 | carboxy-terminal procollagen peptidase | - |
Strongylocentrotus purpuratus |
| 3.4.24.19 | carboxyl-procollagen peptidase | - |
Gallus gallus |
| 3.4.24.19 | carboxyl-procollagen peptidase | - |
Mus musculus |
| 3.4.24.19 | carboxyl-procollagen peptidase | - |
Homo sapiens |
| 3.4.24.19 | carboxyl-procollagen peptidase | - |
Xenopus laevis |
| 3.4.24.19 | carboxyl-procollagen peptidase | - |
Strongylocentrotus purpuratus |
| 3.4.24.19 | mammalian tolloid | - |
Mus musculus |
| 3.4.24.19 | mammalian tolloid | - |
Homo sapiens |
| 3.4.24.19 | MtlD | - |
Mus musculus |
| 3.4.24.19 | MtlD | - |
Homo sapiens |
| 3.4.24.19 | PCP | - |
Gallus gallus |
| 3.4.24.19 | PCP | - |
Mus musculus |
| 3.4.24.19 | PCP | - |
Homo sapiens |
| 3.4.24.19 | PCP | - |
Xenopus laevis |
| 3.4.24.19 | PCP | - |
Strongylocentrotus purpuratus |
| 3.4.24.19 | PCP-1 | - |
Gallus gallus |
| 3.4.24.19 | PCP-1 | - |
Mus musculus |
| 3.4.24.19 | PCP-1 | - |
Homo sapiens |
| 3.4.24.19 | PCP-2 | - |
Gallus gallus |
| 3.4.24.19 | PCP-2 | - |
Mus musculus |
| 3.4.24.19 | PCP-2 | - |
Homo sapiens |
| 3.4.24.19 | procollagen C-peptidase | - |
Gallus gallus |
| 3.4.24.19 | procollagen C-peptidase | - |
Mus musculus |
| 3.4.24.19 | procollagen C-peptidase | - |
Homo sapiens |
| 3.4.24.19 | procollagen C-peptidase | - |
Xenopus laevis |
| 3.4.24.19 | procollagen C-peptidase | - |
Strongylocentrotus purpuratus |
| 3.4.24.19 | Procollagen C-proteinase | - |
Gallus gallus |
| 3.4.24.19 | Procollagen C-proteinase | - |
Mus musculus |
| 3.4.24.19 | Procollagen C-proteinase | - |
Homo sapiens |
| 3.4.24.19 | Procollagen C-proteinase | - |
Rattus norvegicus |
| 3.4.24.19 | Procollagen C-proteinase | - |
Xenopus laevis |
| 3.4.24.19 | Procollagen C-proteinase | - |
Strongylocentrotus purpuratus |
| 3.4.24.19 | suBMP-1 | - |
Strongylocentrotus purpuratus |
| 3.4.24.19 | Tld | - |
Gallus gallus |
| 3.4.24.19 | tolloid | - |
Gallus gallus |
| 3.4.24.19 | XBMP1-A | - |
Xenopus laevis |
| 3.4.24.19 | XBMP1-B | - |
Xenopus laevis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.19 | 8 | 8.5 | - |
Homo sapiens |
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