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Literature summary extracted from

  • Babe, L.M.; Schmidt, B.F.
    Granzyme K (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner; j. F. , eds. )Academic Press, 2, 1552-1554.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B4 3,4-dichloroisocoumarin complete inhibition at 0.1 mM Homo sapiens
3.4.21.B4 Aprotinin complete inhibition at 0.015 mM Homo sapiens
3.4.21.B4 diisopropylfluorophosphate complete inhibition at 0.1 mM Homo sapiens
3.4.21.B4 inter-alpha-trypsin inhibitor complete inhibition at 66 nM Homo sapiens
3.4.21.B4 L-Phe-L-Pro-L-Arg-chloromethyl ketone complete inhibition at 0.1 mM Homo sapiens
3.4.21.B4 leupeptin 50% inhibition at 0.2 mM Homo sapiens
3.4.21.B4 phenylmethylsulfonyl fluoride complete inhibition at 2 mM Homo sapiens
3.4.21.B4 Tos-Lys-CH2Cl complete inhibition at 0.1 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B4 25000
-
 reducing SDS-PAGE Homo sapiens
3.4.21.B4 28000
-
 non-reducing SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B4 Homo sapiens
-
-
-
3.4.21.B4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B4 lung mRNA exptression Homo sapiens
-
3.4.21.B4 natural killer cell mRNA exptression Homo sapiens
-
3.4.21.B4 spleen mRNA exptression Homo sapiens
-
3.4.21.B4 thymus mRNA exptression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B4 Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly + H2O
-
 Homo sapiens Cys-Gly-Tyr-Gly-Pro-Lys + Lys-Lys-Arg + Lys-Val-Gly-Gly
-
 ?
3.4.21.B4 Z-Arg-thiobenzyl ester + H2O
-
 Homo sapiens Z-Arg + thiobenzyl alcohol
-
 ?
3.4.21.B4 Z-Lys-thiobenzyl ester + H2O
-
 Homo sapiens Z-Lys + thiobenzyl alcohol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B4 granzyme 3
-
 Homo sapiens
3.4.21.B4 granzyme K
-
 Homo sapiens
3.4.21.B4 granzyme K
-
 Rattus norvegicus
3.4.21.B4 RNK-Tryp-2
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.B4 7.5
-
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.21.B4 Homo sapiens predicted from sequence
-
 10.2