EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.22.B14 | - |
Murine hepatitis virus |
3.4.22.B50 | vaccinia-T1-mediated expression of a cDNA clone encoding the MHV PLP2 domain | Alphacoronavirus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.B14 | E-64d | membrane-permeable do the irreversible cysteine proteinase inhibitor E-64 blocks cleavage of p65 in vivo | Murine hepatitis virus | |
3.4.22.B14 | leupeptin | blocks the ability of PLP1 to cleave p28 in vitro but not in vivo due to permeability and toxicity issues | Murine hepatitis virus | |
3.4.22.B14 | ZnCl2 | blocks the ability of PLP1 to cleave p28 in vitro but not in vivo due to permeability and toxicity issues | Murine hepatitis virus | |
3.4.22.B50 | additional information | not sensitive to cysteine protease inhibitor E-64d | Alphacoronavirus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.22.B14 | 28000 | - |
- |
Murine hepatitis virus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.B14 | p28 | Murine hepatitis virus | - |
? | - |
? | |
3.4.22.B14 | p65 | Murine hepatitis virus | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.B14 | Murine hepatitis virus | - |
- |
- |
3.4.22.B50 | Alphacoronavirus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.22.B14 | - |
Murine hepatitis virus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.B14 | p28 | - |
Murine hepatitis virus | ? | - |
? | |
3.4.22.B14 | p65 | - |
Murine hepatitis virus | ? | - |
? | |
3.4.22.B50 | PLP2-MP1 precursor polyprotein + H2O | - |
Alphacoronavirus | MP1 + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.B14 | first papain-like cysteine proteinase | - |
Murine hepatitis virus |
3.4.22.B14 | PLP1 | - |
Murine hepatitis virus |
3.4.22.B50 | papain-like cysteine proteinase | - |
Alphacoronavirus |
3.4.22.B50 | PLP2 | - |
Alphacoronavirus |