EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.40 | additional information | binding to nucleic acids, preferably single-stranded DNA or RNA, is required for enzyme activity | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.22.40 | DNA sequence determination | Rattus norvegicus |
3.4.22.40 | DNA sequence determination | Oryctolagus cuniculus |
3.4.22.40 | DNA sequence determination and analysis, chromosome localization at 19q11.2 | Homo sapiens |
3.4.22.40 | gene YCP1 or BLH1, DNA sequence determination | Saccharomyces cerevisiae |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.22.40 | additional information | mutant pre3-2 is inactive with substrate Z-Leu-Leu-Glu-NH-4-nitroanilide, but can be complemented b ythe wild-type gene | Saccharomyces cerevisiae |
3.4.22.40 | V443I | the naturally occurring polymorphism of the gene encoding the enzyme is associated to sporadic Alzheimer's disease and to the amyloid precursor protein | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.40 | 4-hydroxymeruribenzoate | - |
Homo sapiens | |
3.4.22.40 | 4-hydroxymeruribenzoate | - |
Oryctolagus cuniculus | |
3.4.22.40 | 4-hydroxymeruribenzoate | - |
Rattus norvegicus | |
3.4.22.40 | 4-hydroxymeruribenzoate | - |
Streptomyces verticillus | |
3.4.22.40 | E64 | - |
Homo sapiens | |
3.4.22.40 | E64 | - |
Oryctolagus cuniculus | |
3.4.22.40 | E64 | - |
Rattus norvegicus | |
3.4.22.40 | E64 | - |
Streptomyces verticillus | |
3.4.22.40 | iodoacetate | - |
Homo sapiens | |
3.4.22.40 | iodoacetate | - |
Oryctolagus cuniculus | |
3.4.22.40 | iodoacetate | - |
Rattus norvegicus | |
3.4.22.40 | iodoacetate | - |
Streptomyces verticillus | |
3.4.22.40 | leupeptin | weak inhibition | Rattus norvegicus | |
3.4.22.40 | additional information | no inhibition by leupeptin | Homo sapiens | |
3.4.22.40 | additional information | no inhibition by cystatin A and cystatin C | Rattus norvegicus | |
3.4.22.40 | additional information | no inhibition by leupeptin | Streptomyces verticillus | |
3.4.22.40 | NEM | - |
Homo sapiens | |
3.4.22.40 | NEM | - |
Oryctolagus cuniculus | |
3.4.22.40 | NEM | - |
Rattus norvegicus | |
3.4.22.40 | NEM | - |
Streptomyces verticillus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.22.40 | additional information | a self-compartmentalizing enzyme | Homo sapiens | - |
- |
3.4.22.40 | additional information | a self-compartmentalizing enzyme | Rattus norvegicus | - |
- |
3.4.22.40 | additional information | a self-compartmentalizing enzyme | Oryctolagus cuniculus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.40 | additional information | glycometalloenzyme | Streptomyces verticillus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.22.40 | 300000 | - |
about | Homo sapiens |
3.4.22.40 | 300000 | - |
about | Rattus norvegicus |
3.4.22.40 | 300000 | - |
about | Oryctolagus cuniculus |
3.4.22.40 | 300000 | - |
about | Streptomyces verticillus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.40 | bleomycin + H2O | Rattus norvegicus | detoxification reaction | ? | - |
? | |
3.4.22.40 | bleomycin + H2O | Oryctolagus cuniculus | detoxification reaction | ? | - |
? | |
3.4.22.40 | bleomycin + H2O | Homo sapiens | detoxification reaction, high enzyme expression level leads to resistance against the drug | ? | - |
? | |
3.4.22.40 | additional information | Saccharomyces cerevisiae | the enzyme expression is regulated by galactose and Gal4p,expression pattrern | ? | - |
? | |
3.4.22.40 | Z-Leu-Leu-Glu-NH-4-nitroanilide + H2O | Saccharomyces cerevisiae | no activity in vitro due to requirement of binding to DNA-recognition sites of ztranscriptional activator Gal4p | Z-Leu-Leu-Glu + 4-nitroaniline | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.40 | Homo sapiens | - |
- |
- |
3.4.22.40 | Oryctolagus cuniculus | - |
- |
- |
3.4.22.40 | Rattus norvegicus | - |
- |
- |
3.4.22.40 | Saccharomyces cerevisiae | - |
gene YCP1 or BLH1 | - |
3.4.22.40 | Streptomyces verticillus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.22.40 | glycoprotein | glycometalloenzyme | Streptomyces verticillus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.40 | brain | - |
Homo sapiens | - |
3.4.22.40 | Burkitt's lymphoma cell | high expression level | Homo sapiens | - |
3.4.22.40 | leukemia cell | high expression level | Homo sapiens | - |
3.4.22.40 | additional information | no expression in Hodgkin's lymphoma cells | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.40 | bleomycin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.22.40 | bleomycin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.22.40 | bleomycin + H2O | detoxification reaction | Rattus norvegicus | ? | - |
? | |
3.4.22.40 | bleomycin + H2O | detoxification reaction | Oryctolagus cuniculus | ? | - |
? | |
3.4.22.40 | bleomycin + H2O | detoxification reaction, high enzyme expression level leads to resistance against the drug | Homo sapiens | ? | - |
? | |
3.4.22.40 | bleomycin A2 + H2O | preferred to bleomycin B | Homo sapiens | ? | - |
? | |
3.4.22.40 | bleomycin B2 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.22.40 | additional information | the enzyme expression is regulated by galactose and Gal4p,expression pattrern | Saccharomyces cerevisiae | ? | - |
? | |
3.4.22.40 | additional information | the substrate specificity is controlled by the opening of the barrel structure and the positioning of the enzyme's C-terminus in the active site as opposed to the features of the substrate, mechanism, overview | Homo sapiens | ? | - |
? | |
3.4.22.40 | additional information | the substrate specificity is controlled by the opening of the barrel structure and the positioning of the enzyme's C-terminus in the active site as opposed to the features of the substrate, mechanism, overview | Rattus norvegicus | ? | - |
? | |
3.4.22.40 | additional information | the substrate specificity is controlled by the opening of the barrel structure and the positioning of the enzyme's C-terminus in the active site as opposed to the features of the substrate, mechanism, overview | Oryctolagus cuniculus | ? | - |
? | |
3.4.22.40 | Z-Leu-Leu-Glu-NH-4-nitroanilide + H2O | no activity in vitro due to requirement of binding to DNA-recognition sites of ztranscriptional activator Gal4p | Saccharomyces cerevisiae | Z-Leu-Leu-Glu + 4-nitroaniline | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.22.40 | hexamer | homohexamer, three-dimensional structure | Homo sapiens |
3.4.22.40 | hexamer | homohexamer, three-dimensional structure | Rattus norvegicus |
3.4.22.40 | hexamer | homohexamer, three-dimensional structure | Oryctolagus cuniculus |
3.4.22.40 | hexamer | homohexamer, three-dimensional structure | Streptomyces verticillus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.22.40 | BH | - |
Homo sapiens |
3.4.22.40 | BH | - |
Rattus norvegicus |
3.4.22.40 | BH | - |
Saccharomyces cerevisiae |
3.4.22.40 | BH | - |
Oryctolagus cuniculus |
3.4.22.40 | BH | - |
Streptomyces verticillus |
3.4.22.40 | Gal6p | - |
Saccharomyces cerevisiae |
3.4.22.40 | More | the enzyme belongs to the C1B peptidase family | Homo sapiens |
3.4.22.40 | More | the enzyme belongs to the C1B peptidase family | Rattus norvegicus |
3.4.22.40 | More | the enzyme belongs to the C1B peptidase family | Saccharomyces cerevisiae |
3.4.22.40 | More | the enzyme belongs to the C1B peptidase family | Oryctolagus cuniculus |
3.4.22.40 | yeast cysteine protease | - |
Saccharomyces cerevisiae |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.22.40 | 6.5 | 7 | - |
Streptomyces verticillus |
3.4.22.40 | 7 | 7.5 | - |
Oryctolagus cuniculus |
3.4.22.40 | 7.2 | - |
- |
Homo sapiens |
3.4.22.40 | 7.5 | - |
- |
Saccharomyces cerevisiae |