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Literature summary extracted from

  • Hanbauer, I.; Moskovitz, J.
    The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A (2006), Free Radic. Biol. Med., 40, 1391-1396.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.4.11 additional information H2O2 induces MsrA expression in a thioredoxin-dependent manner, msrA promoter and calcium phospholipid binding protein, CPBP, form a complex and enhance msrA expression, cytosolic thioredoxins 1 and 2 are involved in the regulation Saccharomyces cerevisiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 gene msrA, msrA promoter and calcium phopsholipid binding protein, CPBP, form a complex and enhance msrA expression in absence of presence of H2O2, cytosolic thioredoxins 1 and 2 are involved in the regulation, overview Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
1.8.4.11 additional information thioredoxin-deficient yeast strains show increased sensitivity to H2O2 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin Saccharomyces cerevisiae MsrA regulation, overview peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin Saccharomyces cerevisiae BY4743 MsrA regulation, overview peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Saccharomyces cerevisiae
-
 gene msrA
-
1.8.4.11 Saccharomyces cerevisiae BY4743
-
 gene msrA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 dabsyl-L-methionine-(S)-S-oxide + DTT stereospecific reduction Saccharomyces cerevisiae dabsyl-L-methionine + DTT disulfide + H2O
-
 ?
1.8.4.11 dabsyl-L-methionine-(S)-S-oxide + DTT stereospecific reduction Saccharomyces cerevisiae BY4743 dabsyl-L-methionine + DTT disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Saccharomyces cerevisiae peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin MsrA regulation, overview Saccharomyces cerevisiae peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Saccharomyces cerevisiae BY4743 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin MsrA regulation, overview Saccharomyces cerevisiae BY4743 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Saccharomyces cerevisiae
1.8.4.11 MsrA
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.4.11 37
-
 assay at Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.4.11 7
-
 assay at Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin cytosolic thioredoxins 1 and 2 are involved in regulation of MsrA exression Saccharomyces cerevisiae