BRENDA - Enzyme Database

Electrostatic influence of active-site waters on the nucleophilic aromatic substitution catalyzed by 4-chlorobenzoyl-CoA dehalogenase

Xu, D.; Guo, H.; FEBS Lett. 579, 4249-4253 (2005)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.8.1.7
Pseudomonas sp.
A5JTM5
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.8.1.7
4-chlorobenzoyl-CoA + H2O
electrostatic influence of active-site waters on the nucleophilic aromatic substitution catalyzed by 4-chlorobenzoyl-CoA dehalogenase. A quantum mechanical/molecular mechanical simulation of the potential of mean force for the substitution step conforms the increased barrier height in the H90Q mutant and provides the increased barrier height in the H90Q mutant and provides evidence on the electrostatic influence of two-site waters on the rate-limiting barrier
668613
Pseudomonas sp.
4-hydroxybenzoyl-CoA + chloride
-
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.8.1.7
4-chlorobenzoyl-CoA + H2O
electrostatic influence of active-site waters on the nucleophilic aromatic substitution catalyzed by 4-chlorobenzoyl-CoA dehalogenase. A quantum mechanical/molecular mechanical simulation of the potential of mean force for the substitution step conforms the increased barrier height in the H90Q mutant and provides the increased barrier height in the H90Q mutant and provides evidence on the electrostatic influence of two-site waters on the rate-limiting barrier
668613
Pseudomonas sp.
4-hydroxybenzoyl-CoA + chloride
-
-
-
?