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Literature summary extracted from

  • Bidle, K.A.; Hanson, T.E.; Howell, K.; Nannen, J.
    HMG-CoA reductase is regulated by salinity at the level of transcription in Haloferax volcanii (2006), Extremophiles, 11, 49-55.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.34 gene hmgR, expression analysis under different salinity growth conditions, hmgR transcript increases in abundance with increasing salinity by a factor of 2.2fold Haloferax volcanii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 soluble
-
 Haloferax volcanii
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.34 46000
-
 x * 46000, SDS-PAGE Haloferax volcanii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Haloferax volcanii HMGR is a key enzyme in the mevalonate pathway of isoprenoid biosynthesis, the sole route in haloarchaea for lipid and carotenoid production (R)-mevalonate + 2 NADP+ + CoA
-
 ?
1.1.1.34 additional information Haloferax volcanii HMG-CoA reductase is regulated by salinity at the level of transcription ?
-
 ?
1.1.1.34 additional information Haloferax volcanii the expression of HMGR is regulated in response to non-optimal salinity in the halophilic archaeon ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Haloferax volcanii
-
-
-
1.1.1.34 Haloferax volcanii
-
 gene hmgR
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 additional information growth at high and low salinity, quantitative expression analysis, overview, the expression of HMGR is regulated in response to non-optimal salinity in the halophilic archaeon Haloferax volcanii
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.34 0.69
-
 native enzyme in cell extract soluble fraction Haloferax volcanii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Haloferax volcanii (R)-mevalonate + 2 NADP+ + CoA
-
 ?
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ HMGR is a key enzyme in the mevalonate pathway of isoprenoid biosynthesis, the sole route in haloarchaea for lipid and carotenoid production Haloferax volcanii (R)-mevalonate + 2 NADP+ + CoA
-
 ?
1.1.1.34 additional information HMG-CoA reductase is regulated by salinity at the level of transcription Haloferax volcanii ?
-
 ?
1.1.1.34 additional information the expression of HMGR is regulated in response to non-optimal salinity in the halophilic archaeon Haloferax volcanii ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.34 ? x * 46000, SDS-PAGE Haloferax volcanii

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG-CoA reductase
-
 Haloferax volcanii
1.1.1.34 HMGR
-
 Haloferax volcanii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.34 22
-
 assay at room temperature Haloferax volcanii

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Haloferax volcanii