Literature summary extracted from

Dev, K.K.; Chatterjee, S.; Osinde, M.; Stauffer, D.; Morgan, H.; Kobialko, M.; Dengler, U.; Rueeger, H.; Martoglio, B.; Rovelli, G.
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals (2006), Eur. J. Pharmacol., 540, 10-17.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.85	additional information	gamma-sectretase inhibitor LY411575 is not inhibitory for enzyme	Chlorocebus aethiops

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.85	Chlorocebus aethiops	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.85	COS-7 cell	-	Chlorocebus aethiops	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
3.4.24.85	additional information	-	validation of cellular assay for enzyme and S1P endopeptidase activity based on release of N-terminus of sterol regulatory element binding protein driving the expression of a luciferase reporter gene	Chlorocebus aethiops

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Release 2023.1 (January 2023)