Literature summary extracted from

Douglas, G.C.; OBryan, M.K.; Hedger, M.P.; Lee, D.K.; Yarski, M.A.; Smith, A.I.; Lew, R.A.
The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis (2004), Endocrinology, 145, 4703-4711.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.17.23	expression of recombinant ACE2 in P-selectin-transfected Chinese hamster ovary cells	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.17.23	Homo sapiens	Q9BYF1	angiotensin-converting enzyme 2 precursor	-
3.4.17.23	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.17.23	Leydig cell	ACE2 may participate in the control of the testicular function	Rattus norvegicus	-
3.4.17.23	Leydig cell	ACE2 may participate in the control of the testicular function	Homo sapiens	-
3.4.17.23	Sertoli cell	-	Homo sapiens	-
3.4.17.23	testis	ACE2 may participate in the control of the testicular function	Rattus norvegicus	-
3.4.17.23	testis	ACE2 may participate in the control of the testicular function	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.17.23	(7-methoxycoumarin-4-yl)acetyl-APK(2,4-dinitrophenyl) + H2O	-	Rattus norvegicus	(7-methoxycoumarin-4-yl)acetyl-AP + N6-(2,4-dinitrophenyl)-L-lysine	-	?
3.4.17.23	(7-methoxycoumarin-4-yl)acetyl-APK(2,4-dinitrophenyl) + H2O	-	Homo sapiens	(7-methoxycoumarin-4-yl)acetyl-AP + N6-(2,4-dinitrophenyl)-L-lysine	-	?
3.4.17.23	angiotensin II + H2O	-	Rattus norvegicus	angiotensin-(1-7) + Phe	-	?
3.4.17.23	angiotensin II + H2O	-	Homo sapiens	angiotensin-(1-7) + Phe	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.17.23	ACE2	-	Rattus norvegicus
3.4.17.23	ACE2	-	Homo sapiens
3.4.17.23	angiotensin-converting enzyme	-	Rattus norvegicus
3.4.17.23	angiotensin-converting enzyme	-	Homo sapiens

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Release 2023.1 (January 2023)