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Literature summary extracted from
- Calpain inhibition: a therapeutic strategy targeting multiple disease states (2006), Curr. Pharm. Des., 12, 615-638.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.4.22.B24 | - |
Rattus norvegicus |
| 3.4.22.B24 | - |
Sus scrofa |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.52 | additional information | Homo sapiens | pathological conditions associated with the gene of calpain 1: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, neurodegenerative disorders, cataracts, cancer | ? | - |
? |  |
| 3.4.22.53 | additional information | Homo sapiens | pathological conditions associated with the gene of calpain 2: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, Parkinson's disease, neurodegenerative disorders, cataracts, cancer | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.B24 | Homo sapiens | - |
- |
- |
| 3.4.22.B24 | Rattus norvegicus | - |
- |
- |
| 3.4.22.B24 | Sus scrofa | - |
- |
- |
| 3.4.22.52 | Homo sapiens | P07384 | calpain-1 catalytic subunit | - |
| 3.4.22.53 | Homo sapiens | P07384 | calpain-1 catalytic subunit | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.52 | additional information | pathological conditions associated with the gene of calpain 1: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, neurodegenerative disorders, cataracts, cancer | Homo sapiens | ? | - |
? | |
| 3.4.22.53 | additional information | pathological conditions associated with the gene of calpain 2: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, Parkinson's disease, neurodegenerative disorders, cataracts, cancer | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.52 | calpain 1 | - |
Homo sapiens |
| 3.4.22.53 | calpain 2 | - |
Homo sapiens |
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