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Literature summary extracted from

  • Schneider, P.B.; Denk, U.; Breitenbach, M.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Himly, M.; Mari, A.; Ebner, C.; Simon-Nobbe, B.
    Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen (2006), Clin. Exp. Allergy, 36, 1513-1524.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.138 expressed in Escherichia coli Alternaria alternata

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.138 D-fructose substrate inhibition occurred at concentrations above 750 mM Alternaria alternata

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.138 0.0187
-
 NADPH +/- 0.0035 mM, pH 7.0, room temperature Alternaria alternata
1.1.1.138 0.0187
-
 NADPH plusminus 0.0035 mM, pH 7.0, room temperature Alternaria alternata
1.1.1.138 474
-
 D-fructose +/- 80 mM, pH 7.0, room temperature Alternaria alternata
1.1.1.138 474
-
 D-fructose plusminus 80 mM, pH 7.0, room temperature Alternaria alternata

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.138 28610
-
-
 Alternaria alternata

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.138 Alternaria alternata P0C0Y4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.138 D-fructose + NADPH + H+
-
 Alternaria alternata D-mannitol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.138 MtDH
-
 Alternaria alternata
1.1.1.138 NADP-dependent mannitol dehydrogenase
-
 Alternaria alternata

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.138 NADP+
-
 Alternaria alternata
1.1.1.138 NADPH
-
 Alternaria alternata

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.1.1.138 Alternaria alternata
-
-
 5.88