Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Warner, F.J.; Smith, A.I.; Hooper, N.M.; Turner, A.J.
    Angiotensin-converting enzyme-2: a molecular and cellular perspective (2004), Cell. Mol. Life Sci., 61, 2704-2713.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 angiotensin I
-
 Homo sapiens
3.4.17.23 DX600 IC50: 10 nM Homo sapiens
3.4.17.23 MLN-4760 i.e. (SS) 2-[(1)-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]ethylamino]-4-methyl-pentanoic acid, IC50: 0.44 nM Homo sapiens
3.4.17.23 Pro-Phe IC50: 0.15 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 additional information Homo sapiens the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O
-
 Homo sapiens angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + Phe
-
 ?
3.4.17.23 angiotensin IV + H2O
-
 Homo sapiens VYIHP + Phe
-
 ?
3.4.17.23 apelin-13 + H2O
-
 Homo sapiens QRPRLSHKGPMP + Phe
-
 ?
3.4.17.23 apelin-36 + H2O
-
 Homo sapiens ?
-
 ?
3.4.17.23 beta-casomorphin + H2O
-
 Homo sapiens YPFVEP + Ile
-
 ?
3.4.17.23 des-Arg9-bradykinin + H2O
-
 Homo sapiens RPPGFSP + Phe
-
 ?
3.4.17.23 dynorphin A(1-13) + H2O
-
 Homo sapiens YGGFLRRIRPKL + Lys
-
 ?
3.4.17.23 ghrelin + H2O
-
 Homo sapiens ?
-
 ?
3.4.17.23 Lys-des-Arg9 bradykinin + H2O
-
 Homo sapiens KRPPGFSP + Phe
-
 ?
3.4.17.23 additional information the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor Homo sapiens ?
-
 ?
3.4.17.23 additional information no hydrolysis of angiotensin (1-9), angiotensin (1-7), bradikinin, bradykinin(1-7), neurotensin(1-13) Homo sapiens ?
-
 ?
3.4.17.23 neurotensin(1-11) + H2O
-
 Homo sapiens pELYENKPRRP + Tyr
-
 ?
3.4.17.23 neurotensin(1-8) + H2O
-
 Homo sapiens pELYENKP + Arg
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.17.23 0.0000028
-
 DX600
-
 Homo sapiens
3.4.17.23 0.0022
-
 angiotensin I
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.17.23 0.00000044
-
 i.e. (SS) 2-[(1)-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]ethylamino]-4-methyl-pentanoic acid, IC50: 0.44 nM Homo sapiens MLN-4760
3.4.17.23 0.00001
-
 IC50: 10 nM Homo sapiens DX600
3.4.17.23 0.15
-
 IC50: 0.15 mM Homo sapiens Pro-Phe