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Literature summary extracted from
- Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme (2005), Bioorg. Med. Chem. Lett., 15, 2970-2973.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | 1-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]-1,3,5-triazinane-2,4,6-trione | IC50: 0.0073 mM | Sus scrofa |  |
| 3.4.24.86 | 5-(4-acetylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.00062 mM | Sus scrofa | |
| 3.4.24.86 | 5-(4-benzylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000195 mM | Sus scrofa | |
| 3.4.24.86 | 5-(4-hexylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000081 mM | Sus scrofa | |
| 3.4.24.86 | 5-(4-methylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000091 mM | Sus scrofa | |
| 3.4.24.86 | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]dihydropyrimidine-2,4(1H,3H)-dione | IC50: 0.0037 mM | Sus scrofa | |
| 3.4.24.86 | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.00103 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-(1-methylethyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000096 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.00054 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-(2,2-dimethylpropyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.00016 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-(pyridin-3-ylcarbonyl)pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000535 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperazin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.0011 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperidin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000855 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(2-phenylethyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000084 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(3-phenylpropyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.00011 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(4-nitrophenyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.0028 mM | Sus scrofa | |
| 3.4.24.86 | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(methylsulfonyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.000275 mM | Sus scrofa | |
| 3.4.24.86 | methyl 4-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,5-dioxoimidazolidine-4-carboxylate | IC50: 0.0047 mM | Sus scrofa | |
| 3.4.24.86 | tert-butyl 4-(5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperazine-1-carboxylate | IC50: 0.00016 mM | Sus scrofa | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | Sus scrofa | - |
- |
- |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.86 | 0.000081 | - |
IC50: 0.000081 mM | Sus scrofa | 5-(4-hexylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.000084 | - |
IC50: 0.000084 mM | Sus scrofa | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(2-phenylethyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.000091 | - |
IC50: 0.000091 mM | Sus scrofa | 5-(4-methylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.000096 | - |
IC50: 0.000096 mM | Sus scrofa | 5-[4-(1-methylethyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.00011 | - |
IC50: 0.00011 mM | Sus scrofa | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(3-phenylpropyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.00016 | - |
IC50: 0.00016 mM | Sus scrofa | 5-[4-(2,2-dimethylpropyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.00016 | - |
IC50: 0.00016 mM | Sus scrofa | tert-butyl 4-(5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperazine-1-carboxylate | |
| 3.4.24.86 | 0.000195 | - |
IC50: 0.000195 mM | Sus scrofa | 5-(4-benzylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.000275 | - |
IC50: 0.000275 mM | Sus scrofa | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(methylsulfonyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.000535 | - |
IC50: 0.000535 mM | Sus scrofa | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-(pyridin-3-ylcarbonyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.00054 | - |
IC50: 0.00054 mM | Sus scrofa | 5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.00062 | - |
IC50: 0.00062 mM | Sus scrofa | 5-(4-acetylpiperazin-1-yl)-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.000855 | - |
IC50: 0.000855 mM | Sus scrofa | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperidin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.00103 | - |
IC50: 0.00103 mM | Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.0011 | - |
IC50: 0.0011 mM | Sus scrofa | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-piperazin-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.0028 | - |
IC50: 0.0028 mM | Sus scrofa | 5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-5-[4-(4-nitrophenyl)piperazin-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 3.4.24.86 | 0.0037 | - |
IC50: 0.0037 mM | Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]dihydropyrimidine-2,4(1H,3H)-dione | |
| 3.4.24.86 | 0.0047 | - |
IC50: 0.0047 mM | Sus scrofa | methyl 4-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2,5-dioxoimidazolidine-4-carboxylate | |
| 3.4.24.86 | 0.0073 | - |
IC50: 0.0073 mM | Sus scrofa | 1-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]-1,3,5-triazinane-2,4,6-trione | |
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