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Literature summary extracted from

  • Abe, N.; Baba, A.; Takii, R.; Nakayama, K.; Kamaguchi, A.; Shibata, Y.; Abiko, Y.; Okamoto, K.; Kadowaki, T.; Yamamoto, K.
    Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA genes (2004), Biol. Chem., 385, 1041-1047.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.37 carbobenzoxy-Lys-Arg-CO-Lys-N(CH3)2 i.e. KYT-1, specific inhibition of Rgp, inhibits coaggregation of Porphyromonas gingivalis with other bacteria in vivo Porphyromonas gingivalis
3.4.22.37 D-arginine complete inhibition of coaggregation of Porphyromonas gingivalis with other oral bacteria by L- and D-arginine Porphyromonas gingivalis
3.4.22.37 L-arginine complete inhibition of coaggregation of Porphyromonas gingivalis with other oral bacteria by L- and D-arginine Porphyromonas gingivalis
3.4.22.47 KYT-36 specific inhibition of Kgp, slightly inhibits coaggregation of Porphyromonas gingivalis with other bacteria in vivo Porphyromonas gingivalis
3.4.22.47 lysine slight inhibition of coaggregation of Porphyromonas gingivalis with other oral bacteria by L-lysine and more slightly by D-lysine Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.37 additional information Porphyromonas gingivalis gingipains R mediate coaggregation of Porphyromonas gingivalis with other bacteria, overview ?
-
 ?
3.4.22.47 additional information Porphyromonas gingivalis gingipain K adds to gingipain R-mediated coaggregation of Porphyromonas gingivalis with other oral bacteria, it is a virulence factor, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.37 Porphyromonas gingivalis
-
 strain ATCC 33277, gene rgp, encoding enzyme Rgp
-
3.4.22.47 Porphyromonas gingivalis
-
 strain ATCC 33277, gene kgp
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.37 additional information gingipains R mediate coaggregation of Porphyromonas gingivalis with other bacteria, overview Porphyromonas gingivalis ?
-
 ?
3.4.22.47 additional information gingipain K adds to gingipain R-mediated coaggregation of Porphyromonas gingivalis with other oral bacteria, it is a virulence factor, overview Porphyromonas gingivalis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.37 More Rgp possesses C-terminal a hemagglutinin domain containing the proteins responsible for coaggregation activity of Porphyromonas gingivalis, overview Porphyromonas gingivalis

Synonyms

EC Number Synonyms Comment Organism
3.4.22.37 Arg-gingipain
-
 Porphyromonas gingivalis
3.4.22.37 Arg-specific gingipain protease
-
 Porphyromonas gingivalis
3.4.22.37 RGP
-
 Porphyromonas gingivalis
3.4.22.47 KGP
-
 Porphyromonas gingivalis
3.4.22.47 Lys-gingipain
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.37 22
-
 coaggregation assay at room temperature Porphyromonas gingivalis
3.4.22.47 22
-
 coaggregation assay at room temperature Porphyromonas gingivalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.37 8
-
 coaggregation assay at Porphyromonas gingivalis
3.4.22.47 8
-
 coaggregation assay at Porphyromonas gingivalis