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Literature summary extracted from

  • Carloto, A.; Costas, M.J.; Cameselle, J.C.; McLennan, A.G.; Ribeiro, J.M.
    The specific, submicromolar-K(m) ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn(2+) as activating cation and increase in K(m) for ADP-ribose, both eli (2006), Biochim. Biophys. Acta, 1760, 1545-1551.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.13 fluoride inhibition of Mg2+-dependent activity of ADP-ribose pyrophosphatase. the Mn2+-dependent activity is not affected by fluoride Homo sapiens
3.6.1.13 Mn2+ above 0.05 mM Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.13 Co2+ marginally effective in activation Homo sapiens
3.6.1.13 Mg2+ strictly requires Mg2+ (more than 1 mM) or Mn2+ for full activity. Treatment with H2O2 changes the specificity of both ADP-ribose activities for the activating divalent cation, giving them a marked preference for Mn2+ and rendering them virtually inactive with Mg2+ Homo sapiens
3.6.1.13 Mn2+ strictly requires Mg2+ or Mn2+ (0.05 mM) for full activity. Treatment with H2O2 changes the specificity of both ADP-ribose activities for the activating divalent cation, giving them a marked preference for Mn2+ and rendering them virtually inactive with Mg2+ Homo sapiens
3.6.1.13 Zn2+ marginally effective in activation Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.13 36000 37000 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.13 ADP-ribose + H2O Homo sapiens protective enzyme whose function is to limit the intracellular accumulation of ADP-ribose AMP + D-ribose 5-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.13
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.13 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.13 ADP-ribose + H2O
-
 Homo sapiens AMP + D-ribose 5-phosphate
-
 ?
3.6.1.13 ADP-ribose + H2O protective enzyme whose function is to limit the intracellular accumulation of ADP-ribose Homo sapiens AMP + D-ribose 5-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.13 NUDT9 protein
-
 Homo sapiens
3.6.1.13 submicromolar-K(m) ADP-ribose pyrophosphatase
-
 Homo sapiens