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Literature summary extracted from

  • Terlecki, G.; Czapinska, E.; Rogozik, K.; Lisowski, M.; Gutowicz, J.
    Investigation of the interaction of pig muscle lactate dehydrogenase with acidic phospholipids at low pH (2006), Biochim. Biophys. Acta, 1758, 133-144.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 cardiolipin IC50: 0.00005 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa
1.1.1.27 phosphatidylserine IC50: 0.0013 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 skeletal muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 pyruvate + NADH + H+
-
Sus scrofa (S)-lactate + NAD+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 NADH
-
Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.27 0.00005
-
IC50: 0.00005 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa cardiolipin
1.1.1.27 0.0013
-
IC50: 0.0013 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa phosphatidylserine