Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kim, T.; Nelson, P.S.; Kedishvili, N.Y.
    Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids (2005), Biochemistry, 44, 7035-7047.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.300 0.0001
-
 11-cis-retinal pH 7.4, 37°C Homo sapiens
1.1.1.300 0.00014
-
 9-cis-retinal pH 7.4, 37°C Homo sapiens
1.1.1.300 0.0004
-
 all-trans-retinal
-
 Homo sapiens
1.1.1.300 0.00074
-
 NADPH pH 7.4, 37°C Homo sapiens
1.1.1.300 0.0012
-
 NADPH pH 7.4, 37°C Homo sapiens
1.1.1.300 0.0012
-
 NADP+ pH 7.4, 37°C Homo sapiens
1.1.1.300 0.0016
-
 11-cis-retinol pH 7.4, 37°C Homo sapiens
1.1.1.300 0.0016
-
 9-cis-retinol pH 7.4, 37°C Homo sapiens
1.1.1.300 0.0032
-
 NADP+ pH 7.4, 37°C Homo sapiens
1.1.1.300 0.004
-
 all-trans-retinol pH 7.4, 37°C Homo sapiens
1.1.1.300 2.22
-
 NADH pH 7.4, 37°C Homo sapiens
1.1.1.300 2.42
-
 NADH pH 7.4, 37°C Homo sapiens
1.1.1.300 7.75
-
 NAD+ pH 7.4, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.300 microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.300 365000
-
 molecular mass of RDH12-His6 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.300 11-cis-retinal + NADPH + H+ Homo sapiens
-
 11-cis-retinol + NADP+
-
 r
1.1.1.300 all-trans retinal + NADPH + H+ Homo sapiens
-
 all-tans-retinol + NADP+
-
 r
1.1.1.300 n-nonanal + NADPH + H+ Homo sapiens might play a role in detoxification of lipid peroxidation products n-nonanol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.300 Homo sapiens
-
-
-
1.1.1.300 Homo sapiens Q96NR8
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.300
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.300 11-cis-retinal + NADH + H+ NADH much less efficient than NADPH Homo sapiens 11-cis-retinol + NAD+
-
 r
1.1.1.300 11-cis-retinal + NADPH + H+
-
 Homo sapiens 11-cis-retinol + NADP+
-
 ?
1.1.1.300 11-cis-retinal + NADPH + H+
-
 Homo sapiens 11-cis-retinol + NADP+
-
 r
1.1.1.300 9-cis-retinol + NADP+
-
 Homo sapiens 9-cis-retinal + NADPH + H+
-
 ?
1.1.1.300 all-trans retinal + NADH + H+ NADH much less efficient than NADPH Homo sapiens all-tans-retinol + NAD+
-
 r
1.1.1.300 all-trans retinal + NADPH + H+
-
 Homo sapiens all-tans-retinol + NADP+
-
 r
1.1.1.300 all-trans-retinal + NADPH + H+
-
 Homo sapiens all-trans-retinol + NADP+
-
 ?
1.1.1.300 n-nonanal + NADPH + H+ might play a role in detoxification of lipid peroxidation products Homo sapiens n-nonanol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.300 RDH12
-
 Homo sapiens
1.1.1.300 retinol dehydrogenase 12
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.300 NAD+ NAD+ much less efficient than NADP+ Homo sapiens
1.1.1.300 NADH NADH much less efficient than NADPH Homo sapiens
1.1.1.300 NADP+
-
 Homo sapiens
1.1.1.300 NADPH
-
 Homo sapiens