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Literature summary extracted from

  • Tsiftsoglou, S.A.; Willis, A.C.; Li, P.; Chen, X.; Mitchell, D.A.; Rao, Z.; Sim, R.B.
    The catalytically active serine protease domain of human complement factor I (2005), Biochemistry, 44, 6239-6249.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.45 4-(2-aminoethyl)benzenesulfonyl fluoride 0.25 mM, inhibits SP domain form and fI Homo sapiens
3.4.21.45 antipain 0.1 mM, inhibits SP domain form and fI Homo sapiens
3.4.21.45 Aprotinin 0.005 mM, inhibits SP domain form and fI Homo sapiens
3.4.21.45 factor H inhibits SP domain form Homo sapiens
3.4.21.45 leupeptin 0.01 mM, inhibits SP domain form and fI Homo sapiens
3.4.21.45 suramin 1 mM, inhibits fI Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.45 38000
-
SP-domain-form, SDS-PAGE Homo sapiens
3.4.21.45 88000
-
fI, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.45 complement component C3(NH3) + H2O Homo sapiens cleaved by SP domain-form ?
-
?
3.4.21.45 complement component C3b + H2O Homo sapiens
-
complement component iC3b a major opsonin ?
3.4.21.45 complement component C4b + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.45 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.45 generation of intact form of SP domain, purifiaction by affinity chromatography on MRC-OX21-Sepharose Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.45 complement component C3(NH3) + H2O cleaved by SP domain-form Homo sapiens ?
-
?
3.4.21.45 complement component C3b + H2O
-
Homo sapiens complement component iC3b a major opsonin ?
3.4.21.45 complement component C4b + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.45 factor I
-
Homo sapiens
3.4.21.45 fI
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.45 additional information complement component C4bp Homo sapiens
3.4.21.45 additional information complement receptor 1 Homo sapiens
3.4.21.45 additional information factor H Homo sapiens
3.4.21.45 additional information membrane cofactor protein Homo sapiens