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Literature summary extracted from

  • Pedicord, D.L.; Seiffert, D.; Blat, Y.
    Substrate-dependent modulation of the mechanism of factor XIa inhibition (2004), Biochemistry, 43, 11883-11888.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.27 Aprotinin
-
 Homo sapiens
3.4.21.27 leupeptin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.27 0.151
-
 factor IX at 22°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.27 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.27 factor IX + H2O FIX Homo sapiens factor IXa + ?
-
 ?
3.4.21.27 L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide + H2O
-
 Homo sapiens L-pyroglutamyl-L-prolyl-L-arginine + p-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.27 factor XIa
-
 Homo sapiens
3.4.21.27 FXIa
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.27 0.66
-
 factor IX at 22°C Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.27 0.52
-
 Aprotinin L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide substrate, free FXIa Homo sapiens
3.4.21.27 0.96
-
 Aprotinin FIX substrate, free FXIa Homo sapiens
3.4.21.27 1.43
-
 leupeptin L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide substrate, free FXIa Homo sapiens
3.4.21.27 2.91
-
 leupeptin FIX substrate, free FXIa Homo sapiens
3.4.21.27 10.42
-
 Aprotinin FIX substrate, FXIa-FIX complex Homo sapiens
3.4.21.27 19.12
-
 leupeptin FIX substrate, FXIa-FIX complex Homo sapiens
3.4.21.27 209
-
 leupeptin L-pyroglutamyl-L-prolyl-L-arginyl-p-nitroanilide substrate, FXIa-FIX complex Homo sapiens