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Literature summary extracted from
- Biotinylation of histones by human serum biotinidase: assessment of biotinyl-transferase activity in sera from normal individuals and children with biotinidase deficiency (1995), Biochem. Mol. Med., 56, 76-83.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.12 | biotin | - |
Homo sapiens |  |
| 3.5.1.12 | p-hydroxymercuribenzoate | inhibits biotinidase hydrolase activity and biotinyl-transferase activity | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.12 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.12 | blood serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.12 | biocytin + H2O | i.e. biotin-epsilon-lysine. Because polylysine is readily biotinylated by biotinidase in the presence of biocytin, whereas polyarginine is not biotinylated, the enzyme likely transfers biotin to the epsilon-amino group of lysyl residues | Homo sapiens | biotin + L-lysine | - |
? | |
| 3.5.1.12 | biotinyl-4-aminobenzoic acid + H2O | - |
Homo sapiens | biotin + 4-aminobenzoic acid | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.12 | 4.5 | 6 | hydrolysis of biocytin | Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.12 | 0.02 | - |
biotin | pH 5.5 | Homo sapiens | |
| 3.5.1.12 | 0.485 | - |
biotin | pH 7 | Homo sapiens | |
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Release 2023.1 (January 2023)
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