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Literature summary extracted from

  • Day, J.P.; Houslay, M.D.; Davies, S.A.
    A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP (2006), Biochem. J., 393, 481-488.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.35 generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules Drosophila sp. (in: flies)

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 zaprinast
-
 Drosophila sp. (in: flies)

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.35 membrane generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes Drosophila sp. (in: flies) 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.35 additional information Drosophila sp. (in: flies) role for cG-PDE in modulating cGMP transport and efflux ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Drosophila sp. (in: flies)
-
 generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates a novel phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.35 additional information role for cG-PDE in modulating cGMP transport and efflux Drosophila sp. (in: flies) ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.35 cG-PDE
-
 Drosophila sp. (in: flies)
3.1.4.35 DmPDE6
-
 Drosophila sp. (in: flies)
3.1.4.35 Drosophila PDE6-like enzyme
-
 Drosophila sp. (in: flies)