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Literature summary extracted from

  • Venaelaeinen, J.I.; Juvonen, R.O.; Garcia-Horsman, J.A.; Wallen, E.A.; Christiaans, J.A.; Jarho, E.M.; Gynther, J.; Maennistoe, P.T.
    Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site (2004), Biochem. J., 382, 1003-1008.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 (2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidine-2-carbaldehyde functional CHO group is the principal factor determining the inhibition kinetics Sus scrofa
3.4.21.26 (2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-L-prolyl]pyrrolidine-2-carbonitrile
-
 Sus scrofa
3.4.21.26 (2S,2'S)-1,1'-(benzene-1,3-diyldicarbonyl)bis[2-(pyrrolidin-1-ylcarbonyl)pyrrolidine]
-
 Sus scrofa
3.4.21.26 2-hydroxy-1-[(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidin-2-yl]ethanone functional CHO group is the principal factor determining the inhibition kinetics Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 N-benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Sus scrofa ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.26 0.000000079
-
 2-hydroxy-1-[(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidin-2-yl]ethanone pH 7.0, 23°C Sus scrofa
3.4.21.26 0.00000015
-
 (2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidine-2-carbaldehyde pH 7.0, 23°C Sus scrofa
3.4.21.26 0.00000039
-
 (2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-L-prolyl]pyrrolidine-2-carbonitrile pH 7.0, 23°C Sus scrofa
3.4.21.26 0.0000118
-
 (2S,2'S)-1,1'-(benzene-1,3-diyldicarbonyl)bis[2-(pyrrolidin-1-ylcarbonyl)pyrrolidine] pH 7.0, 23°C Sus scrofa