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Literature summary extracted from

  • Schallreuter, K.U.; Rubsam, K.; Chavan, B.; Zothner, C.; Gillbro, J.M.; Spencer, J.D.; Wood, J.M.
    Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus (2006), Biochem. Biophys. Res. Commun., 342, 145-152.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 expression analysis in suncellular fractions of melanocytes, overview Homo sapiens
1.8.4.12 expression analysis in subcellular fractions of melanocytes, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.11 cytosol
-
 Homo sapiens 5829
-
1.8.4.11 nucleus
-
 Homo sapiens 5634
-
1.8.4.12 cytosol
-
 Homo sapiens 5829
-
1.8.4.12 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin Homo sapiens MsrA is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin Homo sapiens MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin L-methionine + thioredoxin disulfide + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Homo sapiens
-
-
-
1.8.4.12 Homo sapiens
-
 several splicing variants resulting in three isozymes MsrB1-3
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.11 partially by subcellular fractionation Homo sapiens
1.8.4.12 partially by subcellular fractionation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 epidermis
-
 Homo sapiens
-
1.8.4.11 melanocyte epidermal Homo sapiens
-
1.8.4.11 additional information expression analysis of MsrA Homo sapiens
-
1.8.4.11 skin
-
 Homo sapiens
-
1.8.4.12 epidermis
-
 Homo sapiens
-
1.8.4.12 melanocyte epidermal Homo sapiens
-
1.8.4.12 additional information expression analysis of MsrB isozymes Homo sapiens
-
1.8.4.12 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Homo sapiens peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin MsrA is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin Homo sapiens peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 r
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction, MsrB accepts free and protein-bound substrates Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Homo sapiens
1.8.4.11 MsrA
-
 Homo sapiens
1.8.4.12 methionine sulfoxide reductase B
-
 Homo sapiens
1.8.4.12 MsrB
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Homo sapiens
1.8.4.12 thioredoxin
-
 Homo sapiens