Literature summary extracted from

Colleluori, D.M.; Reczkowski, R.S.; Emig, F.A.; Cama, E.; Cox, J.D.; Scolnick, L.R.; Compher, K.; Jude, K.; Han, S.; Viola, R.E.; Christianson, D.W.; Ash, D.E.
Probing the role of the hyper-reactive histidine residue of arginase (2005), Arch. Biochem. Biophys., 444, 15-26.

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.5.3.1	additional information	mutation of H141 to study its role in catalysis	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.3.1	diethyl dicarbonate	second-order rate constant of 113 per M and s for inactivation process. L-ornithine partially protects, L-ornithine plus borate completely protect	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.3.1	Rattus norvegicus	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
3.5.3.1	L-arginine + H2O = L-ornithine + urea	H141 serves as an acid/base catalyst, deprotonating the metal-bridging water molecule to generate the metal-bridging hydroxide nucleophile, and by protonating the amino group of the product to facilitate its departure	Rattus norvegicus	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.5.3.1	liver	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)