BRENDA - Enzyme Database

Evidence for an ATP-independent long-chain phosphatidylcholine translocator in hepatocyte membranes

Fuchs, M.; Carey, M.C.; Cohen, D.E.; Am. J. Physiol. Gastrointest. Liver Physiol. 273, 1312-1319 (1997)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
7.6.2.1
additional information
no effect by ATP
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
7.6.2.1
additional information
no inhibition by verapamil, no effect by ATP
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
microsome
-
Rattus norvegicus
-
-
7.6.2.1
plasma membrane
canalicular and basolateral
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
7.6.2.1
ATP + phospholipid/out
Rattus norvegicus
the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane
ADP + phosphate + phospholipid/in
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
7.6.2.1
no activity in Xenopus laevis
-
-
-
7.6.2.1
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.1
hepatocyte
-
Rattus norvegicus
-
7.6.2.1
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.6.2.1
additional information
-
-
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + phospholipid/out
-
667175
Rattus norvegicus
ADP + phosphate + phospholipid/in
-
-
-
?
7.6.2.1
ATP + phospholipid/out
the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane
667175
Rattus norvegicus
ADP + phosphate + phospholipid/in
-
-
-
?
7.6.2.1
long-chain phospholipid/out
-
667175
Rattus norvegicus
long-chain phospholipid/in
-
-
-
?
7.6.2.1
phosphatidylcholine/out
L-alpha-1-palmitoyl-2-linoleoyl-labeled substrate
667175
Rattus norvegicus
phosphatidylcholine/in
-
-
-
?
7.6.2.1
phosphatidylethanolamine/out
-
667175
Rattus norvegicus
phosphatidylethanolamine/in
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
7.6.2.1
37
-
assay at
Rattus norvegicus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6.2.1
7.2
-
assay at
Rattus norvegicus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
7.6.2.1
additional information
no effect by ATP
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
7.6.2.1
additional information
no inhibition by verapamil, no effect by ATP
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
microsome
-
Rattus norvegicus
-
-
7.6.2.1
plasma membrane
canalicular and basolateral
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
7.6.2.1
ATP + phospholipid/out
Rattus norvegicus
the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane
ADP + phosphate + phospholipid/in
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.1
hepatocyte
-
Rattus norvegicus
-
7.6.2.1
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.6.2.1
additional information
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + phospholipid/out
-
667175
Rattus norvegicus
ADP + phosphate + phospholipid/in
-
-
-
?
7.6.2.1
ATP + phospholipid/out
the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane
667175
Rattus norvegicus
ADP + phosphate + phospholipid/in
-
-
-
?
7.6.2.1
long-chain phospholipid/out
-
667175
Rattus norvegicus
long-chain phospholipid/in
-
-
-
?
7.6.2.1
phosphatidylcholine/out
L-alpha-1-palmitoyl-2-linoleoyl-labeled substrate
667175
Rattus norvegicus
phosphatidylcholine/in
-
-
-
?
7.6.2.1
phosphatidylethanolamine/out
-
667175
Rattus norvegicus
phosphatidylethanolamine/in
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
7.6.2.1
37
-
assay at
Rattus norvegicus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6.2.1
7.2
-
assay at
Rattus norvegicus