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Literature summary extracted from
- Evidence for an ATP-independent long-chain phosphatidylcholine translocator in hepatocyte membranes (1997), Am. J. Physiol. Gastrointest. Liver Physiol., 273, 1312-1319.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.1 | additional information | no effect by ATP | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.1 | additional information | no inhibition by verapamil, no effect by ATP | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.6.2.1 | microsome | - |
Rattus norvegicus | - |
- |
| 7.6.2.1 | plasma membrane | canalicular and basolateral | Rattus norvegicus | 5886 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.1 | ATP + phospholipid/out | Rattus norvegicus | the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane | ADP + phosphate + phospholipid/in | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.1 | no activity in Xenopus laevis | - |
- |
- |
| 7.6.2.1 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.6.2.1 | hepatocyte | - |
Rattus norvegicus | - |
| 7.6.2.1 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.1 | additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.1 | ATP + phospholipid/out | - |
Rattus norvegicus | ADP + phosphate + phospholipid/in | - |
? | |
| 7.6.2.1 | ATP + phospholipid/out | the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane | Rattus norvegicus | ADP + phosphate + phospholipid/in | - |
? | |
| 7.6.2.1 | long-chain phospholipid/out | - |
Rattus norvegicus | long-chain phospholipid/in | - |
? | |
| 7.6.2.1 | phosphatidylcholine/out | L-alpha-1-palmitoyl-2-linoleoyl-labeled substrate | Rattus norvegicus | phosphatidylcholine/in | - |
? | |
| 7.6.2.1 | phosphatidylethanolamine/out | - |
Rattus norvegicus | phosphatidylethanolamine/in | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.6.2.1 | ATP-independent flippase | - |
no activity in Xenopus laevis |
| 7.6.2.1 | ATP-independent long-chain phosphatidylcholine translocator | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.1 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.1 | 7.2 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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