Literature summary extracted from

Vivekananda, J.; Smith, D.; King, R.J.
Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase (2001), Am. J. Physiol., 281, L98-L107.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.8.27	ceramide	-	Homo sapiens
2.7.8.27	sphingosine	-	Homo sapiens
2.7.8.27	tumor necrosis factor-alpha	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.8.27	ceramide + phosphatidylcholine	Homo sapiens	the enzyme restores homeostasis between sphingomyelin and ceramide pools	sphingomyelin + 1,2-diacyl-sn-glycerol	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.8.27	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.8.27	NCI-H441 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.8.27	ceramide + phosphatidylcholine	-	Homo sapiens	sphingomyelin + 1,2-diacyl-sn-glycerol	-	?
2.7.8.27	ceramide + phosphatidylcholine	the enzyme restores homeostasis between sphingomyelin and ceramide pools	Homo sapiens	sphingomyelin + 1,2-diacyl-sn-glycerol	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.8.27	PC:ceramide phosphocholinetransferase	-	Homo sapiens

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Release 2023.1 (January 2023)