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Literature summary extracted from

  • Lindkvist, B.; Fajardo, I.; Pejler, G.; Borgstrom, A.
    Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B (2006), Pancreatology, 6, 224-231.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.71 additional information the enzyme needs to be proteolytically activated e.g. by trypsin, proelastase 2 is not activated by cathepsin B Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 E-64d
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.71 extracellular pancreatic juice Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.71 Ca2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.71 Homo sapiens
-
-
-
3.4.22.1 Homo sapiens P07858
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.71 proteolytic modification the enzyme needs to be proteolytically activated e.g. by trypsin, proelastase 2 is not activated by cathepsin B Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.71 proelastase 2 from pancreatic juice by anion and cation exchange chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.71 pancreatic juice
-
 Homo sapiens
-
3.4.22.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.71 N-succinyl-Ala-ALa-Pro-Leu-P-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.1 additional information no reaction with procarboxypeptidase and proelastase Homo sapiens ?
-
 ?
3.4.22.1 Nalpha-CBZ-Arg-Arg 7-amido-4-methylcoumarin + H2O 1 mM DTT Homo sapiens Nalpha-CBZ-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 trypsinogen + H2O 1 mM DTT, 1 mM EDTA, pH 4.1, room temperature Homo sapiens trypsin + ?
-
 ?
3.4.22.1 trypsinogen activation peptide + H2O 1 mM DTT, 1 mM EDTA, pH 4.1, room temperature Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.71 Elastase 2
-
 Homo sapiens
3.4.22.1 cathepsin B
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.71 7.5 8 assay at Homo sapiens