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Literature summary extracted from
- Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta (2004), Nucleic Acids Res., 32, 5134-5146.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.99.18 | (pA)10 | - |
Homo sapiens |  |
| 4.2.99.18 | (pA)10*d(pT)10 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)11*d(pT)11 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)12 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)16 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)16*d(pT)16 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)2 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)3 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)4 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)4*d(pT)4 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)6 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)6*d(pT)6 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)8 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)8*d(pT)8 | - |
Homo sapiens | |
| 4.2.99.18 | (pA)9 | - |
Homo sapiens | |
| 4.2.99.18 | (pC)10 | - |
Homo sapiens | |
| 4.2.99.18 | (pC)14 | - |
Homo sapiens | |
| 4.2.99.18 | (pC)2 | - |
Homo sapiens | |
| 4.2.99.18 | (pC)4 | - |
Homo sapiens | |
| 4.2.99.18 | (pC)6 | - |
Homo sapiens | |
| 4.2.99.18 | (pC)8 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)10 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)10*(pA)10 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)11 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)16 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)16*(pA)16 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)4 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)4*(pA)4 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)6 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)6*(pA)6 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)8 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)9 | - |
Homo sapiens | |
| 4.2.99.18 | (pU)9*(pA)9 | - |
Homo sapiens | |
| 4.2.99.18 | AMP | - |
Homo sapiens | |
| 4.2.99.18 | CMP | - |
Homo sapiens | |
| 4.2.99.18 | d(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate)) | - |
Homo sapiens | |
| 4.2.99.18 | d(p(2,3-dihydroxy-5-oxopentyl phosphate)) | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)10 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)10*d(pT)10 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)12 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)12*d(pT)12 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)14 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)14*d(pT)14 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)16 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)16*d(pT)16 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)2 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)2*d(pT)2 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)20*(pT)20 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)4 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)4*d(pT)4 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)6 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)6*d(pT)6 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)8 | - |
Homo sapiens | |
| 4.2.99.18 | d(pA)8*d(pT)8 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)10 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)11 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)13 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)2 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)3 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)5 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)7 | - |
Homo sapiens | |
| 4.2.99.18 | d(pC)9 | - |
Homo sapiens | |
| 4.2.99.18 | d(pG)2 | - |
Homo sapiens | |
| 4.2.99.18 | d(pG)4 | - |
Homo sapiens | |
| 4.2.99.18 | d(pG)6 | - |
Homo sapiens | |
| 4.2.99.18 | d(pG)8 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)10 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)11 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)12 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)14 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)15 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)2 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)3 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)4 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)6 | - |
Homo sapiens | |
| 4.2.99.18 | d(pT)8 | - |
Homo sapiens | |
| 4.2.99.18 | dAMP | - |
Homo sapiens | |
| 4.2.99.18 | dCMP | - |
Homo sapiens | |
| 4.2.99.18 | dGMP | - |
Homo sapiens | |
| 4.2.99.18 | dTMP | - |
Homo sapiens | |
| 4.2.99.18 | d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))3pT] | - |
Homo sapiens | |
| 4.2.99.18 | d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))5pT] | - |
Homo sapiens | |
| 4.2.99.18 | d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))7pT] | - |
Homo sapiens | |
| 4.2.99.18 | d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))9pT] | - |
Homo sapiens | |
| 4.2.99.18 | NaH2PO4 | - |
Homo sapiens | |
| 4.2.99.18 | UMP | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.99.18 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.99.18 | placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.99.18 | (pT)7(p(2,3-dihydroxy-5-oxopentyl phosphate))(pT)6 | - |
Homo sapiens | ? | - |
? | |
| 4.2.99.18 | oligodeoxynucleotide with abasic site 2,3-dihydroxy-5-oxopentyl phosphate | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.99.18 | APE1 | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.99.18 | 0.00033 | - |
d(pA)10*d(pT)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00033 | - |
d(pA)14*d(pT)14 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00033 | - |
d(pA)16*d(pT)16 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00033 | - |
d(pA)20*(pT)20 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00036 | - |
d(pA)12*d(pT)12 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.001 | - |
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))9pT] | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00166 | - |
d(pA)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00166 | - |
d(pA)16 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0017 | - |
d(pA)12 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0017 | - |
d(pA)14 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0023 | - |
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))7pT] | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
d(pT)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
d(pA)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
d(pT)11 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
d(pT)12 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
d(pT)14 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
(pA)10*d(pT)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
(pA)11*d(pT)11 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0025 | - |
(pA)16*d(pT)16 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00257 | - |
d(pT)15 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0033 | - |
d(pC)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0033 | - |
d(pC)11 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0033 | - |
d(pC)13 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0047 | - |
d(pC)9 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0052 | - |
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))5pT] | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0054 | - |
d(pG)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0063 | - |
(pA)8*d(pT)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.00759 | - |
(pA)4*d(pT)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0083 | - |
d(pT)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0093 | - |
d(pA)8*d(pT)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.01 | - |
d(pC)7 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.01 | - |
(pU)10*(pA)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.01 | - |
(pU)16*(pA)16 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0117 | - |
d[(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate))3pT] | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0118 | - |
d(pA)6*d(pT)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0144 | - |
d(pG)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0166 | - |
(pU)6*(pA)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0167 | - |
(pU)9*(pA)9 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0172 | - |
d(pA)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0214 | - |
(pA)6*d(pT)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0217 | - |
d(pC)5 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0246 | - |
d(pT)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.025 | - |
(p(2,3-dihydroxy-5-oxopentyl phosphate)) | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0266 | - |
d(pA)4*d(pT)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0267 | - |
(pA)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0269 | - |
(pA)9 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.03 | - |
(pA)12 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.03 | - |
(pA)16 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.033 | - |
d(pA)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0366 | - |
d(pA)2*d(pT)2 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0367 | - |
(pA)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.038 | - |
(pC)14 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0383 | - |
d(pG)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0447 | - |
(pC)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.045 | - |
d(pT)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.05 | - |
d(pA)2 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.059 | - |
d(p((3-hydroxytetrahydrofuran-2-yl)methyl phosphate)) | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.06 | - |
d(pC)3 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0667 | - |
d(pT)3 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.0708 | - |
(pC)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.1 | - |
(pA)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.102 | - |
d(pG)2 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.1166 | - |
d(pT)2 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.12 | - |
(pC)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.135 | - |
(pU)4*(pA)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.14 | - |
d(pC)2 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.157 | - |
(pU)10 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.158 | - |
(pU)9 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.158 | - |
(pU)16 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.159 | - |
(pU)11 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.1633 | - |
dCMP | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.1633 | - |
dTMP | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.165 | - |
dAMP | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.1666 | - |
dGMP | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.178 | - |
(pU)8 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.183 | - |
(pA)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.199 | - |
(pA)3 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.214 | - |
(pC)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.263 | - |
(pA)2 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.316 | - |
(pC)2 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.339 | - |
(pU)6 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.36 | - |
NaH2PO4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.373 | - |
AMP | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.447 | - |
CMP | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 0.7 | - |
(pU)4 | pH 7.6, 37°C | Homo sapiens | |
| 4.2.99.18 | 1.873 | - |
UMP | pH 7.6, 37°C | Homo sapiens | |
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