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Literature summary extracted from

  • Tambourgi, D.V.; Pedrosa, M.F.; de Andrade, R.M.; Billington, S.J.; Griffiths, M.; van den Berg, C.W.
    Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis (2007), Mol. Immunol., 44, 576-582.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.41 expression in Escherichia coli Corynebacterium pseudotuberculosis
3.1.4.41 expression in Escherichia coli Loxosceles intermedia

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.41 Mg2+ inhibits activity on phosphatidylcholine Corynebacterium pseudotuberculosis
3.1.4.41 Mg2+ inhibits activity on phosphatidylcholine Loxosceles intermedia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.41 sphingomyelin + H2O Loxosceles intermedia bites by Loxosceles spiders can induce severe clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, haemolysis and persistent inflammation. the causative toxin is sphingomyelinase D. Spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis choline + ceramide 1-phosphate
-
?
3.1.4.41 sphingomyelin + H2O Corynebacterium pseudotuberculosis spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis choline + ceramide 1-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.41 Corynebacterium pseudotuberculosis
-
-
-
3.1.4.41 Corynebacterium pseudotuberculosis
-
recombinant fusion protein composed of the mature PLD protein with a 33 amino acid N-terminal extension containing a 6His tag
-
3.1.4.41 Loxosceles intermedia
-
-
-
3.1.4.41 Loxosceles intermedia
-
recombinant fusion protein with 36 amino acid N-terminal extension containing a 6His tag
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.41 venom
-
Loxosceles intermedia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.41 2-lysophosphatidylcholine + H2O
-
Corynebacterium pseudotuberculosis 2-lysophosphatidate + choline
-
?
3.1.4.41 2-lysophosphatidylcholine + H2O
-
Loxosceles intermedia 2-lysophosphatidate + choline
-
?
3.1.4.41 phosphatidylcholine + H2O no activity in presence of Mg2+ Corynebacterium pseudotuberculosis phosphatidic acid + choline
-
?
3.1.4.41 phosphatidylcholine + H2O no activity in presence of Mg2+ Loxosceles intermedia phosphatidic acid + choline
-
?
3.1.4.41 sphingomyelin + H2O
-
Corynebacterium pseudotuberculosis choline + ceramide 1-phosphate
-
?
3.1.4.41 sphingomyelin + H2O
-
Loxosceles intermedia choline + ceramide 1-phosphate
-
?
3.1.4.41 sphingomyelin + H2O bites by Loxosceles spiders can induce severe clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, haemolysis and persistent inflammation. the causative toxin is sphingomyelinase D. Spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis Loxosceles intermedia choline + ceramide 1-phosphate
-
?
3.1.4.41 sphingomyelin + H2O spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis Corynebacterium pseudotuberculosis choline + ceramide 1-phosphate
-
?
3.1.4.41 sphingomyelin + H2O
-
Corynebacterium pseudotuberculosis ceramide-1-phosphate + choline
-
?
3.1.4.41 sphingomyelin + H2O
-
Loxosceles intermedia ceramide-1-phosphate + choline
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.41 PLD
-
Corynebacterium pseudotuberculosis
3.1.4.41 SMase D
-
Corynebacterium pseudotuberculosis
3.1.4.41 SMase D
-
Loxosceles intermedia
3.1.4.41 SMase P1
-
Loxosceles intermedia
3.1.4.41 sphingomyelinase D
-
Corynebacterium pseudotuberculosis
3.1.4.41 sphingomyelinase D
-
Loxosceles intermedia