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Literature summary extracted from

  • Ravingerova, T.; Barancik, M.; Strniskova, M.
    Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology (2003), Mol. Cell. Biochem., 247, 127-138.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Mus musculus
2.7.11.24 additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Homo sapiens
2.7.11.24 additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Rattus norvegicus
2.7.11.24 additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Sus scrofa
2.7.11.24 additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Oryctolagus cuniculus
2.7.11.24 additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Canis lupus familiaris

Application

EC Number Application Comment Organism
2.7.11.24 drug development MAPKs are targets for drug development Mus musculus
2.7.11.24 drug development MAPKs are targets for drug development Homo sapiens
2.7.11.24 drug development MAPKs are targets for drug development Rattus norvegicus
2.7.11.24 drug development MAPKs are targets for drug development Sus scrofa
2.7.11.24 drug development MAPKs are targets for drug development Oryctolagus cuniculus
2.7.11.24 drug development MAPKs are targets for drug development Canis lupus familiaris
2.7.11.24 medicine MAPKs are therapeutic targets in cardiac pathology Homo sapiens
2.7.11.24 pharmacology MAPKs are targets for inhibitors and pharmacological drug development Mus musculus
2.7.11.24 pharmacology MAPKs are targets for inhibitors and pharmacological drug development Homo sapiens
2.7.11.24 pharmacology MAPKs are targets for inhibitors and pharmacological drug development Rattus norvegicus
2.7.11.24 pharmacology MAPKs are targets for inhibitors and pharmacological drug development Sus scrofa
2.7.11.24 pharmacology MAPKs are targets for inhibitors and pharmacological drug development Oryctolagus cuniculus
2.7.11.24 pharmacology MAPKs are targets for inhibitors and pharmacological drug development Canis lupus familiaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 additional information Homo sapiens signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
 ?
2.7.11.24 additional information Rattus norvegicus signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
 ?
2.7.11.24 additional information Mus musculus signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
 ?
2.7.11.24 additional information Sus scrofa signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
 ?
2.7.11.24 additional information Oryctolagus cuniculus signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
 ?
2.7.11.24 additional information Canis lupus familiaris signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Canis lupus familiaris
-
-
-
2.7.11.24 Homo sapiens
-
-
-
2.7.11.24 Mus musculus
-
-
-
2.7.11.24 Oryctolagus cuniculus
-
-
-
2.7.11.24 Rattus norvegicus
-
-
-
2.7.11.24 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Mus musculus
2.7.11.24 phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Homo sapiens
2.7.11.24 phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Rattus norvegicus
2.7.11.24 phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Sus scrofa
2.7.11.24 phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Oryctolagus cuniculus
2.7.11.24 phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Canis lupus familiaris

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 heart
-
 Mus musculus
-
2.7.11.24 heart
-
 Homo sapiens
-
2.7.11.24 heart
-
 Rattus norvegicus
-
2.7.11.24 heart
-
 Sus scrofa
-
2.7.11.24 heart
-
 Oryctolagus cuniculus
-
2.7.11.24 heart
-
 Canis lupus familiaris
-
2.7.11.24 myocardium the MAPK family enzymes have regulatory function in the myocardium Mus musculus
-
2.7.11.24 myocardium the MAPK family enzymes have regulatory function in the myocardium Homo sapiens
-
2.7.11.24 myocardium the MAPK family enzymes have regulatory function in the myocardium Rattus norvegicus
-
2.7.11.24 myocardium the MAPK family enzymes have regulatory function in the myocardium Sus scrofa
-
2.7.11.24 myocardium the MAPK family enzymes have regulatory function in the myocardium Oryctolagus cuniculus
-
2.7.11.24 myocardium the MAPK family enzymes have regulatory function in the myocardium Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Homo sapiens ?
-
 ?
2.7.11.24 additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Rattus norvegicus ?
-
 ?
2.7.11.24 additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Mus musculus ?
-
 ?
2.7.11.24 additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Sus scrofa ?
-
 ?
2.7.11.24 additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Oryctolagus cuniculus ?
-
 ?
2.7.11.24 additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Canis lupus familiaris ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 ERK1
-
 Mus musculus
2.7.11.24 ERK1
-
 Homo sapiens
2.7.11.24 ERK1
-
 Rattus norvegicus
2.7.11.24 ERK1
-
 Sus scrofa
2.7.11.24 ERK1
-
 Oryctolagus cuniculus
2.7.11.24 ERK1
-
 Canis lupus familiaris
2.7.11.24 ERK2
-
 Mus musculus
2.7.11.24 ERK2
-
 Homo sapiens
2.7.11.24 ERK2
-
 Rattus norvegicus
2.7.11.24 ERK2
-
 Sus scrofa
2.7.11.24 ERK2
-
 Oryctolagus cuniculus
2.7.11.24 ERK2
-
 Canis lupus familiaris
2.7.11.24 JNK
-
 Mus musculus
2.7.11.24 JNK
-
 Homo sapiens
2.7.11.24 JNK
-
 Rattus norvegicus
2.7.11.24 JNK
-
 Sus scrofa
2.7.11.24 JNK
-
 Oryctolagus cuniculus
2.7.11.24 JNK
-
 Canis lupus familiaris
2.7.11.24 MAPK
-
 Mus musculus
2.7.11.24 MAPK
-
 Homo sapiens
2.7.11.24 MAPK
-
 Rattus norvegicus
2.7.11.24 MAPK
-
 Sus scrofa
2.7.11.24 MAPK
-
 Oryctolagus cuniculus
2.7.11.24 MAPK
-
 Canis lupus familiaris
2.7.11.24 More the enzyme belongs to the MAPK superfamily of enzymes Mus musculus
2.7.11.24 More the enzyme belongs to the MAPK superfamily of enzymes Homo sapiens
2.7.11.24 More the enzyme belongs to the MAPK superfamily of enzymes Rattus norvegicus
2.7.11.24 More the enzyme belongs to the MAPK superfamily of enzymes Sus scrofa
2.7.11.24 More the enzyme belongs to the MAPK superfamily of enzymes Oryctolagus cuniculus
2.7.11.24 More the enzyme belongs to the MAPK superfamily of enzymes Canis lupus familiaris
2.7.11.24 p38-MAPK
-
 Mus musculus
2.7.11.24 p38-MAPK
-
 Homo sapiens
2.7.11.24 p38-MAPK
-
 Rattus norvegicus
2.7.11.24 p38-MAPK
-
 Sus scrofa
2.7.11.24 p38-MAPK
-
 Oryctolagus cuniculus
2.7.11.24 p38-MAPK
-
 Canis lupus familiaris
2.7.11.24 SAPK
-
 Mus musculus
2.7.11.24 SAPK
-
 Homo sapiens
2.7.11.24 SAPK
-
 Rattus norvegicus
2.7.11.24 SAPK
-
 Sus scrofa
2.7.11.24 SAPK
-
 Oryctolagus cuniculus
2.7.11.24 SAPK
-
 Canis lupus familiaris

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
 Mus musculus
2.7.11.24 ATP
-
 Homo sapiens
2.7.11.24 ATP
-
 Rattus norvegicus
2.7.11.24 ATP
-
 Sus scrofa
2.7.11.24 ATP
-
 Oryctolagus cuniculus
2.7.11.24 ATP
-
 Canis lupus familiaris