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Literature summary extracted from

  • Marco-Marํn, C.; Gil-Ortiz, F.; Rubio, V.
    The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis (2005), J. Mol. Biol., 352, 438-454.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.4.22 drug development UMP kinase may be a potential antimicrobial target Pyrococcus furiosus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.22
-
 Pyrococcus furiosus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.4.22 resolved at 2.4 A resolution. Complexed with AMP-PNP, resolved at 3 A resolution. Complexed with AMP-PNP and UMP, resolved at 2.55 A resolution Pyrococcus furiosus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.22 Mg2+ the crystal structure contains two bound Mg ions, of which one helps stabilize the transition state Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.22 ATP + UMP Pyrococcus furiosus
-
 ADP + UDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.22 Pyrococcus furiosus Q8U122
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.22
-
 Pyrococcus furiosus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.22 ATP + UMP
-
 Pyrococcus furiosus ADP + UDP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.22 hexamer alpha6, organized as a dimer of trimers, crystal structure Pyrococcus furiosus

Synonyms

EC Number Synonyms Comment Organism
2.7.4.22 UMP kinase
-
 Pyrococcus furiosus
2.7.4.22 UMPK
-
 Pyrococcus furiosus