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Literature summary extracted from

  • Chae, Y.C.; Lee, S.; Lee, H.Y.; Heo, K.; Kim, J.H.; Suh, P.G.; Ryu, S.H.
    Inhibition of muscarinic receptor-linked phospholipase D activation by association with tubulin (2005), J. Biol. Chem., 280, 3723-3730.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 tubulin increase in local membrane monomeric tubulin concentration inhibits PLD2 activity by direct interaction, carbachol increases the association between PLD2 with tubulin Chlorocebus aethiops

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 additional information Chlorocebus aethiops increase in local membrane monomeric tubulin concentration inhibits PLD2 activity. The PLD2 regulating mechanism via tubulin exists in endogeneous muscarinic receptor possessing cells ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Chlorocebus aethiops
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 COS-7 cell
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 Chlorocebus aethiops
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information increase in local membrane monomeric tubulin concentration inhibits PLD2 activity. The PLD2 regulating mechanism via tubulin exists in endogeneous muscarinic receptor possessing cells Chlorocebus aethiops ?
-
 ?