Literature summary extracted from

Pedreno, Y.; Maicas, S.; Arguelles, J.C.; Sentandreu, R.; Valentin, E.
The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans (2004), J. Biol. Chem., 279, 40852-40860.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.2.1.28	gene ATC1, DNA and amino acid sequence determination and analysis, expression pattern, subcloning in Escherichia coli, in vitro transcription and translation of HA-tagged enzyme using an Escherichia coli-derived system	Candida albicans

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.2.1.28	additional information	construction of enzyme-deficient mutants by gene disruption at two ATC chromosomal alleles	Candida albicans

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.2.1.28	additional information	reaction product D-glucose suppresses enzyme expression	Candida albicans

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.2.1.28	cell wall	bound to	Candida albicans	5618	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.2.1.28	alpha,alpha-trehalose + H2O	Candida albicans	the enzyme is essential for growth on trehalose as carbon source, regulation by D-glucose repression	2 D-glucose	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.2.1.28	Candida albicans	-	gene ATC1	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
3.2.1.28	glycoprotein	Atc1p contains 20 potential N-glycosylation sites	Candida albicans

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.2.1.28	additional information	expression pattern in presence or absence of D-glucose	Candida albicans	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.2.1.28	alpha,alpha-trehalose + H2O	-	Candida albicans	2 D-glucose	-	?
3.2.1.28	alpha,alpha-trehalose + H2O	the enzyme is essential for growth on trehalose as carbon source, regulation by D-glucose repression	Candida albicans	2 D-glucose	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.2.1.28	acid trehalase	-	Candida albicans
3.2.1.28	Atc1p	-	Candida albicans

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.2.1.28	30	-	assay at	Candida albicans

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
3.2.1.28	6	-	assay at	Candida albicans

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Release 2023.1 (January 2023)