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Literature summary extracted from

  • Morgan, A.J.; Wang, Y.K.; Roberts, M.F.; Miller, S.J.
    Chemistry and biology of deoxy-myo-inositol phosphates: stereospecificity of substrate interactions within an archaeal and a bacterial IMPase (2004), J. Am. Chem. Soc., 126, 15370-15371.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.25 Ca2+
-
 Archaeoglobus fulgidus
3.1.3.25 Ca2+
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.25 additional information
-
 additional information reaction kinetics Escherichia coli
3.1.3.25 additional information
-
 additional information reaction kinetics Archaeoglobus fulgidus
3.1.3.25 0.047
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 0.051
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 0.061
-
 L-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 0.061
-
 D-myo-inositol 3-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 0.068
-
 D-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 0.1
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 0.11
-
 D-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 0.16
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 0.2
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 0.23
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 1.7
-
 L-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 1.7
-
 D-myo-inositol 3-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 2.3
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 4.9
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.25 Mg2+ dependent on Escherichia coli
3.1.3.25 Mg2+ dependent on Archaeoglobus fulgidus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Archaeoglobus fulgidus
-
-
-
3.1.3.25 Escherichia coli
-
 gene suhB
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.25 myo-inositol phosphate + H2O = myo-inositol + phosphate catalytic mechanism and stereospecificity Escherichia coli
a
3.1.3.25 myo-inositol phosphate + H2O = myo-inositol + phosphate catalytic mechanism and stereospecificity Archaeoglobus fulgidus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 3,5-dideoxy-D-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3,5-dideoxy-D-myo-inositol + phosphate
-
 ?
3.1.3.25 3,5-dideoxy-D-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3,5-dideoxy-D-myo-inositol + phosphate
-
 ?
3.1.3.25 3,5-dideoxy-L-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3,5-dideoxy-L-myo-inositol + phosphate
-
 ?
3.1.3.25 3,5-dideoxy-L-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3,5-dideoxy-L-myo-inositol + phosphate
-
 ?
3.1.3.25 3-deoxy-D-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3-deoxy-D-myo-inositol + phosphate
-
 ?
3.1.3.25 3-deoxy-D-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3-deoxy-D-myo-inositol + phosphate
-
 ?
3.1.3.25 3-deoxy-L-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3-deoxy-L-myo-inositol + phosphate
-
 ?
3.1.3.25 3-deoxy-L-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3-deoxy-L-myo-inositol + phosphate
-
 ?
3.1.3.25 D-myo-inositol 1-phosphate + H2O
-
 Escherichia coli D-myo-inositol + phosphate
-
 ?
3.1.3.25 D-myo-inositol 1-phosphate + H2O substrate binding structure, interactions sites with the enzyme involving Tyr155 and Ala172 Archaeoglobus fulgidus D-myo-inositol + phosphate
-
 ?
3.1.3.25 D-myo-inositol 3-phosphate + H2O
-
 Escherichia coli D-myo-inositol + phosphate
-
 ?
3.1.3.25 D-myo-inositol 3-phosphate + H2O
-
 Archaeoglobus fulgidus D-myo-inositol + phosphate
-
 ?
3.1.3.25 L-myo-inositol 1-phosphate + H2O
-
 Escherichia coli L-myo-inositol + phosphate
-
 ?
3.1.3.25 L-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus L-myo-inositol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.25 IMPase
-
 Escherichia coli
3.1.3.25 IMPase
-
 Archaeoglobus fulgidus
3.1.3.25 IMPase/FBPase
-
 Archaeoglobus fulgidus
3.1.3.25 SuhB
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.25 37
-
 assay at Escherichia coli
3.1.3.25 85
-
 assay at Archaeoglobus fulgidus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.3.25 1.4
-
 L-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 1.4
-
 D-myo-inositol 3-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 2.5
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 3.2
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 3.3
-
 D-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 3.6
-
 L-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 3.6
-
 D-myo-inositol 3-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 3.9
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.1.3.25 4
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 4.4
-
 D-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 4.4
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 4.4
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 5.6
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
3.1.3.25 5.8
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.25 8
-
 assay at Escherichia coli
3.1.3.25 8
-
 assay at Archaeoglobus fulgidus