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Literature summary extracted from

  • Straeter, N.; Lipscomb, W.N.
    Leucyl aminopeptidase (animal) (2004), Handbook of Proteolytic Enzymes (2nd Edition), 1, 896-901.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.1 amastatin transition-state analogue Bos taurus
3.4.11.1 amastatin transition-state analogue, low toxicity in vivo Homo sapiens
3.4.11.1 amastatin transition-state analogue Sus scrofa
3.4.11.1 bestatin transition-state analogue Bos taurus
3.4.11.1 bestatin transition-state analogue Homo sapiens
3.4.11.1 bestatin transition-state analogue Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.1 cytosol kidney enzyme Sus scrofa 5829
-
3.4.11.1 additional information the enzyme is associated with the proteasome Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.1 Zn2+ metallopeptidase Homo sapiens
3.4.11.1 Zn2+ metallopeptidase Sus scrofa
3.4.11.1 Zn2+ metallopeptidase Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.1 additional information Homo sapiens the enzyme has tissue-specifici physiological roles, e.g. trimmíng of the N-terminus of antigenic peptides for presentation or in eye cataract, overview ?
-
 ?
3.4.11.1 additional information Sus scrofa the enzyme has tissue-specifici physiological roles, overview ?
-
 ?
3.4.11.1 additional information Bos taurus the enzyme has tissue-specifici physiological roles, overview, active site structure and zinc-binding, mechanism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.1 Bos taurus
-
-
-
3.4.11.1 Homo sapiens
-
-
-
3.4.11.1 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.1 native enzyme from kidney to homogeneity Sus scrofa
3.4.11.1 native enzyme from lens to homogeneity Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.1 commercial preparation purified kidney enzyme Sus scrofa
-
3.4.11.1 eye
-
 Homo sapiens
-
3.4.11.1 intestinal mucosa
-
 Sus scrofa
-
3.4.11.1 kidney
-
 Sus scrofa
-
3.4.11.1 lens
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.1 additional information the enzyme has tissue-specifici physiological roles, e.g. trimmíng of the N-terminus of antigenic peptides for presentation or in eye cataract, overview Homo sapiens ?
-
 ?
3.4.11.1 additional information the enzyme has tissue-specifici physiological roles, overview Sus scrofa ?
-
 ?
3.4.11.1 additional information the enzyme has tissue-specifici physiological roles, overview, active site structure and zinc-binding, mechanism Bos taurus ?
-
 ?
3.4.11.1 additional information substrate specificity, overview, active site structure Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.1 LAP
-
 Homo sapiens
3.4.11.1 LAP
-
 Sus scrofa
3.4.11.1 LAP
-
 Bos taurus
3.4.11.1 leucyl aminopeptidase (animal)
-
 Homo sapiens
3.4.11.1 leucyl aminopeptidase (animal)
-
 Sus scrofa
3.4.11.1 leucyl aminopeptidase (animal)
-
 Bos taurus
3.4.11.1 More the enzyme belongs to the peptidase family M17 Homo sapiens
3.4.11.1 More the enzyme belongs to the peptidase family M17 Sus scrofa
3.4.11.1 More the enzyme belongs to the peptidase family M17 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.1 9 9.5 kidney enzyme Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.11.1 0.0000013
-
 amastatin lens enzyme Bos taurus
3.4.11.1 0.0002
-
 amastatin kidney enzyme Sus scrofa